Basic Information

Strain name
C57BL/6-Mertktm1(MERTK)/Bcgen
Common Name
B-hMERTK mice
Background
C57BL/6
Catalog Number
111278
NCBI Gene ID
Aliases
Mertk (Me; Ny; Eyk; Mer; Nyk; nmf1; nmf12)

Targeting strategy

Gene targeting strategy for B-hMERTK mice. The exon 2 of mouse Mertk gene was inserted human MERTK chimeric CDS in B-hMERTK mice.

Protein expression analysis

Strain specific MERTK expression analysis in heterozygous B-hMERTK mice by flow cytometry. Peritoneal washes were collected from wild-type C57BL/6 mice (+/+) and heterozygous B-hMERTK mice (H/+). Flow cytometry analysis of the macrophage was analyzed with species-specific anti-MERTK antibody. Mouse MERTK was detectable in wild-type mice and heterozygote B-hMERTK mice. Human MERTK was only detectable in heterozygote B-hMERTK mice but not in wild-type mice.

Summary

Protein expression analysis:

Mouse MERTK was detectable in wild-type mice and heterozygote B-hMERTK mice. Human MERTK was only detectable in heterozygote B-hMERTK mice but not in wild-type mice..