TNFSF4 encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren’s syndrome and systemic lupus erythematosus.
Protein expression analysis
Species specific OX40L expression analysis in B-hOX40L mice by flow cytometry.
DCs were induced from bone marrow cells from WT and heterozygous B-hOX40L (H/+) mice were analyzed by flow cytometry with anti- OX40L antibodies. Mouse OX40 was detectable in WT and heterozygous B-hOX40L mice. Human OX40L was exclusively detectable in heterozygous B-hOX40L but not WT mice.