Basic Information

Strain name
C57BL/6-Tnfsf4tm1(TNFSF4)/Bcgen
Stock Number
110043
Common name
B-hTNFSF4(OX40L )mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related genes
OX40L (TNF superfamily member 4)
Species
C57BL/6
Appearance
Black
Genotypes
heterozygous

Description

TNFSF4 encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren’s syndrome and systemic lupus erythematosus.

Details

Protein expression analysis

Species specific OX40L expression analysis in B-hOX40L mice by flow cytometry.

DCs were induced from bone marrow cells from WT and heterozygous B-hOX40L (H/+) mice were analyzed by flow cytometry with anti- OX40L antibodies. Mouse OX40 was detectable in WT and heterozygous B-hOX40L mice. Human OX40L was exclusively detectable in heterozygous B-hOX40L but not WT mice.

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