Basic Information
Strain Name
C57BL/6-Pdcd1tm1(PDCD1) Btlatm1(BTLA) /Bcgen
Stock Number
120517
Common Name
B-hPD-1/hBTLA mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
PD-1 (Programmed death-1); BTLA (B and T lymphocyte associated)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous
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Targeting Strategy
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Details
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Phenotype
Protein Expression Analysis
Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. Mouse BTLA+ B cells were detectable in the WT C57BL/6 mice, while human BTLA+ B cells were detectable in the homozygous B-hPD-1/hBTLA mice.
Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detectable in the WT C57BL/6 mice, while human PD-1+ T cells were detectable in the homozygous B-hPD-1/hBTLA mice.
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References
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- J Immunol. 2005 Mar 15;174(6):3377-85.
- Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):289-95. doi: 10.1007/s00417-011-1695-8. Epub 2011 Jul 22.
- J Leukoc Biol. 2010 Feb;87(2):223-35. doi: 10.1189/jlb.0809590. Epub 2009 Dec 9.
- Nat Commun. 2017 Feb 6;8:14369. doi: 10.1038/ncomms14369.
- EMBO J. 1992 Nov;11(11):3887-95.
- J Exp Med. 2000 Oct 2;192(7):1027-34.
- Science. 2001 Jan 12;291(5502):319-22.
