B-hPD-L1/hCD40 Mice

Basic Information

Strain Name
C57BL/6-Cd274tm1(CD274) Cd40tm1(CD40)/Bcgen
Stock Number
120536
Common Name
B-hPD-L1/hCD40 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Cd40 (CD40 antigen); Cd274 (CD274 antigen)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

Gene targeting strategy for B-hPD-L1/hCD40 mice. The exon 3 of mouse Pd-l1 gene that  encodes the extracellular domain was replaced by human PD-L1 exon 3 and  the exons 2-7 of mouse Cd40 gene that  encode the extracellular domain were replaced by human CD40 exons 2-7 in B-hPD-L1/hCD40 mice.

References

  1. Clin Cancer Res 2016; published online Nov 8. DOI:10.1158/1078-0432.CCR-16-1741
  2. Blood First Edition paper, May 11, 2010; DOI 10.1182/blood-2010-02-271874.
  3. J Immunol published online 1 May 2017. doi:10.4049/jimmunol.1601490
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