Gene targeting strategy of B-hPD-L1/hTIM3 mice. The targeting strategy of B-hPD-L1 mice is to the exon 3 of mouse PD-L1 gene that encode the extracellular domain were replaced by human PD-L1 exon 3. The targeting strategy of B-hTIM3 mice is to the exon 2 of mouse Tim3 gene that encode the extracellular domain were replaced by human TIM3 exon 2 . The B-hPD-L1/hTIM3 double knock-in model, was developed by breeding the B-hPD-L1 mice and the B-hTIM3 mice, has a functional mouse immune system.
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