Basic Information

Strain Name
C57BL/6-Pdgfratm2(PDGFRA)/Bcgen
Common Name
B-hPDGFRA mice
Background
C57BL/6
Catalog Number
111709
Alias
PDGFRA (CD140A; PDGFR2; PDGFR-2)
NCBI Gene ID

Targeting Strategy

Gene targeting strategy for B-hPDGFRA mice.

Exons 3-11 of mouse Pdgfra (which encode the extracellular domain) were replaced by human PDGFRA exons 3-11 in B-hPDGFRA mice.

PDGFRA Expression Analysis

Strain specific PDGFRA expression analysis in homozygous B-hPDGFRA mice by Western Blot. lung/cortex/kidney tissues were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPDGFRA mice (H/H), and analyzed by western blot with anti-PDGFRA antibody. Mouse PDGFRA was detectable in wild-type mice. Human PDGFRA was exclusively detected in homozygous humanized B-hPDGFRA mice

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