PDGFRA (CD140A; PDGFR2; PDGFR-2)
NCBI Gene ID
Gene targeting strategy for B-hPDGFRA mice.
Exons 3-11 of mouse Pdgfra (which encode the extracellular domain) were replaced by human PDGFRA exons 3-11 in B-hPDGFRA mice.
PDGFRA Expression Analysis
Strain specific PDGFRA expression analysis in homozygous B-hPDGFRA mice by Western Blot. lung/cortex/kidney tissues were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPDGFRA mice (H/H), and analyzed by western blot with anti-PDGFRA antibody. Mouse PDGFRA was detectable in wild-type mice. Human PDGFRA was exclusively detected in homozygous humanized B-hPDGFRA mice