Basic Information

Strain Name
C57BL/6-Tlr2tm1(TLR2)/Bcgen
Common Name
B-hTLR2 mice
Background
C57BL/6
Catalog Number
111228
Aliases
TLR2 (TIL4; CD282)
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hTLR2 mice. The exon 3 of mouse Tlr2 gene that encodes the extracellular domain was replaced by human TLR2 exon 1 in B-hTLR2 mice.

Protein expression analysis in Gr-1+ cells in spleen

Strain specific TLR2 expression analysis in heterozygous B-hTLR2 mice by flow cytometry. Peritoneal exudative macrophages(PEMs) were collected from wild-type C57BL/6 mice(+/+) and heterozygous B-hLTR2 mice(H/+). Mouse TLR2 was detectable in the WT and heterozygous B-hTLR2 mice, Human TLR2 was exclusively detectable in the heterozygous B-hTLR2 mice.

Summary

Protein expression analysis:

Mouse TLR2 was detectable in the WT and heterozygous B-hTLR2 mice. Human TLR2 was exclusively detectable in the heterozygous B-hTLR2 mice.