Humanized Tumor Cell Lines

The ability to test potential immuno-oncology therapeutics in vivo requires an intact immune system in the disease model. One way to model disease progression is through the use of murine cancer cell lines. 

Murine cancer cell lines are a useful tool to investigate biological processes that govern tumor growth. Specific applications for murine cancer cell lines include in vitro mechanistic studies, and in vivo syngeneic tumor growth assays. For these syngeneic models, an isolated murine cancer cell line is implanted into immunocompetent mice of the same strain/genetic background. The use of syngeneic models allows for successful implantation of tumor cells that are recognized as “self” by the mouse. 

To facilitate your anti-tumor efficacy studies, Biocytogen offers numerous off-the-shelf humanized murine cancer cell lines. When implanted into our humanized immune-checkpoint mice, which are genetically engineered to express human immune checkpoint proteins, in vivo efficacy evaluation of human immune checkpoint antibodies or inhibitors is possible. 

Don’t see the line you’re looking for? Our gene editing team can generate humanized murine cancer cell lines for your specific needs.

Request a Custom Cell Line Here!

Product Organism Disease Strain
B-HLA-E MC38 plus Mus musculus, mouse Colon Carcinoma C57BL/6
B-HLA-E plus/hPD-L1 MC38 Mouse Colon carcinoma C57BL/6
B-Tg(HLA-A0201) Raji (service only) Human Burkitt's lymphoma NA
B-Tg(HLA-A0201-EGFP) A2058 (service only) Human Melanoma NA
B-Tg(HLA-A0201-EGFP) K-562 (service only) Human Chronic myelogenous leukemia NA
B-Tg(HLA-A2.1) A20 (service only) Mouse Reticulum cell sarcoma NA
B-Tg(HLA-A2.1) A20 plus (service only) Mouse Reticulum cell sarcoma NA
B-Tg(HLA-A2.1) MC38 (service only) Mouse Colorectal cancer NA
B-Tg(WT1 peptide-HLA-A2.1) MC38(service only) Mouse Colon carcinoma C57BL/6
B-Tg(hCCL1) MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-Tg(hEGFR) MC38 Mouse Colon carcinoma C57BL/6
B-Tg(hHER2/hTROP2) MC38 Mouse Colon carcinoma C57BL/6
B-Tg(hMICA) MC38 Mouse Colon carcinoma C57BL/6
B-hADAM9 MC38 Mouse Colon carcinoma C57BL/6
B-hALB MC38 Mouse Colon carcinoma C57BL/6
B-hAMHR2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hANXA2 MC38 Mouse Colon carcinoma C57BL/6
B-hAREG MC38 Mouse Colon carcinoma C57BL/6
B-hB2M/HLA-G MC38 Mouse Colon carcinoma C57BL/6
B-hB7-H3 CT26.WT Mus musculus, mouse Colon Carcinoma BALB/c
B-hB7-H3 EL4 Mouse Lymphoma C57BL/6N
B-hB7-H3 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hB7-H4 B16-F10 Mus musculus, mouse Melanoma C57BL/6
B-hB7-H4 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hBCMA CT26.WT Mouse Colon carcinoma BALB/c
B-hBCMA MC38 Mouse Colon carcinoma C57BL/6
B-hBCMA/hGPRC5D MC38 Mouse Colon carcinoma C57BL/6
B-hC5 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCAXII MC38 Mouse Colon carcinoma C57BL/6
B-hCCL2 MC38 Mouse Colon carcinoma C57BL/6
B-hCCR4 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCCR4-luc EL4 Mus musculus, mouse Lymphoma C57BL/6
B-hCCR9 MC38 Mouse Colon carcinoma C57BL/6
B-hCD10 MC38 Mouse Colon carcinoma C57BL/6
B-hCD106 MC38 Mouse Colon carcinoma C57BL/6
B-hCD112 MC38 Mouse Colon carcinoma C57BL/6
B-hCD151 MC38 Mouse Colon carcinoma C57BL/6
B-hCD155 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD19 EL4 Mouse Lymphoma C57BL/6
B-hCD19 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD19-luc GFP A20 Mouse Reticulum cell sarcoma BALB/cAnN
B-hCD20 EL4 Mouse Lymphoma C57BL/6N
B-hCD20 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD20-luc-GFP A20 Mouse Reticulum cell sarcoma BALB/cAnN
B-hCD200 MC38 Mouse Colon carcinoma C57BL/6
B-hCD24 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD36 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD37 MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-hCD38 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD38-Luc E.G7-OVA Mouse Lymphoma C57BL/6
B-hCD39 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD47 CT26.WT Mouse Colon carcinoma BALB/c
B-hCD47 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCD56 MC38 Mouse Colon carcinoma C57BL/6
B-hCD73 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCDH17 B16-F10 Mouse Melanoma C57BL/6
B-hCDH17 MC38 Mouse Colon carcinoma C57BL/6
B-hCEACAM1 MC38 Mus musculus,mouse Colon Carcinoma C57BL/6
B-hCLDN18.2 A549 Human Carcinoma N/A
B-hCLDN18.2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCLDN6 MC38 mouse Colon Carcinoma C57BL/6
B-hCXCR2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCXCR4 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hCXCR5 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hDLL3 B16-F10 Mouse Melanoma C57BL/6
B-hDLL3 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hEFEMP1 MC38 Mouse Colon carcinoma C57BL/6
B-hENPP3 MC38 Mouse Colon carcinoma C57BL/6
B-hEPCAM B16-F10 Mouse Melanoma C57BL/6
B-hEPCAM EL4 Mouse Lymphoma C57BL/6N
B-hEPCAM LLC1 Mouse Lewis lung carcinoma C57BL/6
B-hEPCAM MC38 Mus musculus,mouse Colon Carcinoma C57BL/6
B-hFAP MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-hFGL1 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hFN14 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hFOLR1 MC38 Mouse Colon carcinoma C57BL/6
B-hGAS6 MC38 Mouse Colon carcinoma C57BL/6
B-hGPC3 CT26.WT Mouse Colon carcinoma BALB/c
B-hGPC3 MC38 plus Mouse Colon carcinoma C57BL/6
B-hGPNMB MC38 Mouse Colon carcinoma C57BL/6
B-hGPRC5D MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hGUCY2C MC38 Mouse Colon carcinoma C57BL/6
B-hHER2 CT26.WT Mouse Colon carcinoma BALB/c
B-hHER2 EL4 Mouse Lymphoma C57BL/6N
B-hHER2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hHRH3 MC38 Mouse Colon carcinoma C57BL/6
B-hHVEM MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hIL34 MC38 Mouse Colon carcinoma C57BL/6
B-hIL8 MC38 Mouse Colon carcinoma C57BL/6
B-hITGA7 MC38 Mouse Colon carcinoma C57BL/6
B-hLAIR1-luc EL4 Mus musculus, mouse Lymphoma C57BL/6N
B-hLILRB4 MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-hLILRB4 luc EL4 Mus musculus, mouse Lymphoma C57BL/6
B-hLRRC15 MC38 Mouse Colon carcinoma C57BL/6
B-hLRRN1 MC38 Mouse Colon carcinoma C57BL/6
B-hMERTK MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hMET MC38 Mouse Colon carcinoma C57BL/6
B-hMMP-8 MC38 Mouse Colon carcinoma C57BL/6
B-hMUC1 MC38 Mouse Colon carcinoma C57BL/6
B-hMUC17 MC38 Mouse Colon carcinoma C57BL/6
B-hNECTIN4 MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-hOLFML3 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 B16-F10 Mouse Melanoma C57BL/6
B-hPD-L1 CT26.WT Mouse Colon carcinoma BALB/c
B-hPD-L1 EL4 Mouse Lymphoma C57BL/6N
B-hPD-L1 LLC1 Mouse Lewis lung carcinoma C57BL/6
B-hPD-L1 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPD-L1 MC38 Plus Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPD-L1 Raji-luc Human Burkitt’s lymphoma
B-hPD-L1 low B16-F10 Mus musculus, mouse Melanoma C57BL/6
B-hPD-L1 low MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPD-L1 plus/hCD155 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 plus/hCD47 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPD-L1 plus/hCEA MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPD-L1 plus/hCLDN18.2 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 plus/hHER2 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 plus/hPCSK9 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 plus/hROR1 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1 plus/hTPBG MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1/hB7-H3 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L1/hCD39 MC38 Mouse Colon carcinoma C57BL/6
B-hPD-L2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hPSMA MC38 Mus musculus, mouse Colon carcinoma C57BL/6
B-hROR1 CT26.WT Mouse Colon carcinoma BALB/c
B-hROR1 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hSIGLEC15 CT26.WT Mouse Colon carcinoma BALB/c
B-hSIGLEC15 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hSPN MC38 Mouse Colon carcinoma C57BL/6
B-hSTEAP1 MC38 Mouse Colon carcinoma C57BL/6
B-hTF MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hTNFR2 MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hTPBG B16-F10 Mus musculus, mouse Melanoma C57BL/6
B-hTPBG CT26.WT Mouse Colon carcinoma BALB/c
B-hTPBG MC38 Mus musculus, mouse Colon Carcinoma C57BL/6
B-hTROP2 CT26.WT Mouse Colon carcinoma BALB/c
B-hTROP2 MC38 plus Mus musculus, mouse Colon Carcinoma C57BL/6
B-hVEGFA MC38(service only) Mouse Colon carcinoma C57BL/6
B-hc-MPL MC38 Mouse Colon carcinoma C57BL/6
Comparison of PD-L1 humanized MC38 cell lines
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