Basic Information
Common name
B-luc A20
Catalog number
311118
Aliases
Gt(ROSA)26Sor
Disease
Reticulum cell sarcoma
Strain
BALB/cAnN
Tissue types
Lymphoma
Tissue
B lymphocyte
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Targeting Strategy
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Gene targeting strategy for B-Luc A20 cells. The exogenous promoter and luciferase was inserted into the murine ROSA26 locus.
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Phenotypic Analysis
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Luminescence signal intensity of B-Luc A20 cells. B-Luc A20 cells displayed strong luminescence signal intensity compared to A20-WT cells, as detected by the Bright-GloTM luciferase Assay System (Promega, Cat E2610).
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In Vivo Imaging Analysis
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Tumor growth and in vivo imaging of B-Luc A20 cells. B-Luc A20 cells (5×105) were injected by tail vein into wild-type BALB/c mice. (A) Imaging was performed twice a week for tumor detection and signal intensity analysis. (B) Body weight was measured twice a week (Mean ± SEM). Altogether these data indicate that B-Luc A20 cells can be used for in vivo efficacy evaluation.