Basic Information
Common name
B-luc A20
Catalog number
311118
Aliases
Gt(ROSA)26Sor
Disease
Reticulum cell sarcoma
Strain
BALB/cAnN
Tissue types
Lymphoma
Tissue
B lymphocyte
-
Targeting Strategy
-
Gene targeting strategy for B-Luc A20 cells. The exogenous promoter and luciferase was inserted into the murine ROSA26 locus.
-
Phenotypic Analysis
-
Luminescence signal intensity of B-Luc A20 cells. B-Luc A20 cells displayed strong luminescence signal intensity compared to A20-WT cells, as detected by the Bright-GloTM luciferase Assay System (Promega, Cat E2610).
-
In Vivo Imaging Analysis
-
Tumor growth and in vivo imaging of B-Luc A20 cells. B-Luc A20 cells (5×105) were injected by tail vein into wild-type BALB/c mice. (A) Imaging was performed twice a week for tumor detection and signal intensity analysis. (B) Body weight was measured twice a week (Mean ± SEM). Altogether these data indicate that B-Luc A20 cells can be used for in vivo efficacy evaluation.
