Basic Information

Common name
B-luc A20
Catalog number
311118
Aliases
Gt(ROSA)26Sor
Disease
Reticulum cell sarcoma
Strain
BALB/cAnN
Tissue types
Lymphoma
Tissue
B lymphocyte

Targeting Strategy

Gene targeting strategy for B-Luc A20 cells. The exogenous promoter and luciferase was inserted into the murine ROSA26 locus.

Phenotypic Analysis

Luminescence signal intensity of B-Luc A20 cells. B-Luc A20 cells displayed strong luminescence signal intensity compared to A20-WT cells, as detected by the Bright-GloTM luciferase Assay System (Promega, Cat E2610).

In Vivo Imaging Analysis

Tumor growth and in vivo imaging of B-Luc A20 cells. B-Luc A20 cells (5×105) were injected by tail vein into wild-type BALB/c mice. (A) Imaging was performed twice a week for tumor detection and signal intensity analysis. (B) Body weight was measured twice a week (Mean ± SEM). Altogether these data indicate that B-Luc A20 cells can be used for in vivo efficacy evaluation.

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