Basic Information

Common Name
B-Tg(Luc) A549
Catalog Number
321969
Disease
Lung carcinoma
Organism
Human
Tissue types
Lung
Tissue
Lung
Application
B-Tg(Luc) A549 cell line can be used to evaluate anti-cancer drugs in lung carcinoma in vivo. Liver metastasis models of lung carcinoma can be established by tail vein injection, and provide more models for more drug evaluations.

Description

This B-Tg(Luc) A549 cell line expresses firefly luciferase as a marker of A549 cells. Fluorescence could be detected in B-Tg(Luc) A549 cells.

Targeting strategy

Gene targeting strategy for B-Tg(Luc) A549 cells. The exogenous promoter and luciferase coding sequence were inserted into the mouse genome randomly.

Quantitative imaging data & body weight changes

B-Tg(Luc) A549 cells (1×106, 5×106 ,1×107) were injected into the tail vein of wild-type B-NDG mice. Signal intensity and body weight were measured twice a week. (A) Imaging was performed twice a week. (B) Body weight (Mean ± SEM). B-Tg(Luc) A549 cells can be used for in vivo efficacy evaluation.

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