Basic Information

Strain Name
C57BL/6N-Cd79atm1(CD79A)Bcgen/Bcgen
Common Name
B-hCD79A mice
Background
C57BL/6N
Catalog number
111095
Aliases
IGA; MB-1
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hCD79A mice. The exons 1~3 of mouse Cd79a gene that encode the extracellular domain were replaced by human CD79A counterpart gene in B-hCD79A mice.

Protein expression analysis

 

 

 

 

 

 

 

Species-specific CD79A protein expression analysis in humanized B-hCD79A mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCD79A (H/H) mice, and analyzed by flow cytometry using species-specific anti-CD79A antibodies. Human CD79A protein was only detected in B-hCD79A mice, while mouse CD79A protein was detected in both wild-type and B-hCD79A mice due to the cross-reactive antibody.

Back to top