Basic Information
Strain Name
C57BL/6N-Cd79atm1(CD79A)/Bcgen
Common Name
B-hCD79A mice
Background
C57BL/6N
Catalog number
111095
Aliases
IGA; MB-1
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCD79A mice. The exons 1~3 of mouse Cd79a gene that encode the extracellular domain were replaced by human CD79A counterpart gene in B-hCD79A mice.
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Protein expression analysis
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Species-specific CD79A protein expression analysis in humanized B-hCD79A mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCD79A (H/H) mice, and analyzed by flow cytometry using species-specific anti-CD79A antibodies. Human CD79A protein was only detected in B-hCD79A mice, while mouse CD79A protein was detected in both wild-type and B-hCD79A mice due to the cross-reactive antibody.
