Basic Information
Strain Name
C57BL/6J-Itga6tm1(ITGA6)/Bcgen
Common Name
B-hITGA6 mice
Background
C57BL/6J
Catalog Number
111346
Alias
ITGA6 (CD49f; VLA-6; ITGA6B)
NCBI Gene ID
-
Gene targeting strategy
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Gene targeting strategy for B-hITGA6 mice. Exons 2-23 of the mouse Itga6 gene that encodes the extracellular domain were replaced by human ITGA6 exons 2-23 in B-hITGA6 mice.
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mRNA expression analysis
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Species-specific ITGA6 gene expression analysis in wild-type and humanized B-hITGA6 mice by RT-PCR. Mouse Itga6 mRNA was detected in colon tissue isolated from wild-type C57BL/6 (+/+) mice, while human ITGA6 mRNA was detected in homozygous B-hITGA6 (H/H) mice.
