ITGA6 (CD49f; VLA-6; ITGA6B)
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hITGA6 mice. Exons 2-23 of the mouse Itga6 gene that encodes the extracellular domain were replaced by human ITGA6 exons 2-23 in B-hITGA6 mice.
mRNA expression analysis
Species-specific ITGA6 gene expression analysis in wild-type and humanized B-hITGA6 mice by RT-PCR. Mouse Itga6 mRNA was detected in colon tissue isolated from wild-type C57BL/6 (+/+) mice, while human ITGA6 mRNA was detected in homozygous B-hITGA6 (H/H) mice.