Basic Information

Strain Name
C57BL/6-Itgb1tm1(ITGB1)/Bcgen
Common Name
B-hITGB1 mice
Background
C57BL/6
Catalog number
110901
Related Genes
integrin subunit beta 1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hITGB1 mice.

The exons 2-15 of mouse Itgb1 gene were replaced by human ITGB1 exons 2-15 in B-hITGB1 mice.

Protein expression analysis

Strain specific ITGB1 expression analysis in heterozygous B-hITGB1 mice by flow cytometry.

Splenocytes were collected from C57BL/6 wild-type mice (+/+) and heterozygous B-hITGB1 mice (H/+) analyzed by flow cytometry with species-specific anti-ITGB1 antibody. Mouse ITGB1 was detectable in wild-type mice and heterozygous B-hITGB1 mice (H/+). Human ITGB1 were exclusively detectable in heterozygous B-hITGB1.