Basic Information
Strain Name
C57BL/6-L1camtm1(L1CAM)/Bcgen
Common Name
B-hL1CAM mice
Background
C57BL/6N
Catalog number
111113
Aliases
L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5,
N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, L1 cell adhesion molecule
NCBI Gene ID
-
Gene targeting strategy
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Gene targeting strategy for B-hL1CAM mice. Exons 2-26 of mouse L1cam gene that encodes the extracellular domain and the transmembrane domain were replaced by human L1CAM exons 2-26 in B-hL1CAM mice.
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Protein expression analysis
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Species-specific L1CAM protein expression analysis in wild-type and humanized B-hL1CAM mice. Brain tissue was isolated from wild-type C57BL/6 (+/+) and homozygous B-hL1CAM (H/H) mice and analyzed by flow cytometry using species-specific anti-L1CAM antibodies. Murine L1CAM protein was detected in wild-type mice, while human L1CAM protein was detected in B-hL1CAM mice.
