Basic Information

Strain name
C57BL/6N-Mdktm1(MDK)Bcgen/Bcgen
Common Name
B-hMDK mice
Background
C57BL/6N
Catalog Number
111114
Aliases
MDK: MK, ARAP, NEGF2
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hMDK mice. The exons 2-5 of mouse Mdk gene that encode the full-length protein were replaced by human MDK exons 2-5 in B-hMDK mice.

Protein expression analysis in plasma

Species specific MDK expression analysis in wild-type mice and homozygous mice (H/H) by ELISA. Plasma was collected from wild-type mice (+/+) and homozygous B-hMDK mice (H/H), and then was analyzed by ELISA with mouse and human-specific MDK ELISA kit. Mouse MDK was detectable in wild-type mice and human MDK was detectable in homozygous mice.

Summary

Protein expression analysis:

Human MDK was detectable in plasma of homozygous B-hMDK mice, and mouse MDK was detectable only in wild-type C57BL/6N mice.

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