NPR1 (ANPa; NPRA; ANPRA; GUC2A; GUCY2A)
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hNPR1 mice. Exons 1-7 of the mouse Npr1 gene that encodes the extracellular domain were replaced by human NPR1 exons 1-7 in B-hNPR1 mice.
mRNA expression analysis
Species-specific NPR1 gene expression analysis in wild-type and humanized B-hNPR1 mice by RT-PCR. Murine Npr1 mRNA was detected in ovarian tissue isolated from wild-type C57BL/6 (+/+) mice, while human NPR1 mRNA was detected in homozygous B-hNPR1 (H/H) mice.