Basic Information

Strain Name
C57BL/6-UPARtm1(UPAR)Bcgen/Bcgen
Common Name
B-hUPAR mice 
Background
C57BL/6
Catalog number
111081
Aliases
CD87; UPAR; URKR; U-PAR;PLAUR
NCBI Gene ID

Targeting strategy

Gene targeting strategy. The part of exon 2 and exons 3-7 of mouse Upar gene sequences was replaced by human UPAR counterpart gene sequences in B-hUPAR mice.

Protein expression analysis

UPAR (also named PLAUR) expression analysis in homozygous B-hUPAR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hUPAR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-UPAR antibody. Mouse UPAR was detectable in wild-type mice. Human UPAR was detectable in homozygous B-hUPAR mice.

Summary

Protein expression analysis:

Human UPAR was exclusively detectable in homozygous B-hUPAR mice but not in wild-type mice.

Back to top