Basic Information
Strain Name
C57BL/6-UPARtm1(UPAR)/Bcgen
Common Name
B-hUPAR mice
Background
C57BL/6
Catalog number
111081
Aliases
CD87; UPAR; URKR; U-PAR;PLAUR
NCBI Gene ID
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Targeting strategy
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Gene targeting strategy. The part of exon 2 and exons 3-7 of mouse Upar gene sequences was replaced by human UPAR counterpart gene sequences in B-hUPAR mice.
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Protein expression analysis
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UPAR (also named PLAUR) expression analysis in homozygous B-hUPAR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hUPAR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-UPAR antibody. Mouse UPAR was detectable in wild-type mice. Human UPAR was detectable in homozygous B-hUPAR mice.
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Summary
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Protein expression analysis:
Human UPAR was exclusively detectable in homozygous B-hUPAR mice but not in wild-type mice.
