Basic Information
Strain Name
C57BL/6-Plaurtm1(PLAUR)/Bcgen
Common Name
B-hPLAUR mice
Background
C57BL/6
Catalog number
111081
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy. Part of exon 2 and exons 3-7 of the mouse Plaur gene was replaced by human PLAUR counterpart gene sequences to generate humanized B-hPLAUR mice.
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Protein expression analysis
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PLAUR expression analysis in homozygous B-hPLAUR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hPLAUR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-PLAUR antibody. Mouse PLAUR was detectable in wild-type mice. Human PLAUR was detectable in homozygous B-hPLAUR mice.
