Basic Information

Strain Name
C57BL/6-Plaurtm1(PLAUR)/Bcgen
Common Name
B-hPLAUR mice
Background
C57BL/6J
Catalog number
111081
NCBI Gene ID

Targeting strategy

Gene targeting strategy. Part of exon 2 and exons 3-7 of the mouse Plaur gene was replaced by human PLAUR counterpart gene sequences to generate humanized B-hPLAUR mice.

Protein expression analysis

PLAUR expression analysis in homozygous B-hPLAUR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hPLAUR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-PLAUR antibody. Mouse PLAUR was detectable in wild-type mice. Human PLAUR was detectable in homozygous B-hPLAUR mice.