Basic Information

Strain Name
C57BL/6JNifdc-Ptprctm1(K302E)Bcgen/Bcgen
Stock Number
112593
Common Name
B-CD45.1 mice
Background
C57BL/6JNifdc
Aliases
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105

Targeting strategy

Gene targeting strategy for B-CD45.1 mice. Introduce a lysine to glutamic acid mutation (K302E) in mouse Ptprc gene, resulting the encoding protein can be recognized by anti-CD45.1 antibodies.

Thy1.1 expression analysis in B-Thy1.1 mice

CD45.1 expression analysis in homozygous B-CD45.1 mice by flow cytometry. Spleen, blood and bone marrow were collected from wild-type C57BL/6 mice (+/+) and homozygous B-CD45.1 mice (Mut/Mut), and then analyzed by flow cytometry with anti-CD45.1 or CD45.2 antibodies. CD45.2 was detection in C57BL/6 mice. CD45.1 were only detectable in B-CD45.1 mice but not in wild-type mice.

Publication

Lin F, Yu H, Zhang L, Zhou J, Cao Y, Wu S, Wang J. Differential expression of interleukin-35 receptor distinguishes different subsets of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in a mouse endometriosis model. Mol Immunol. 2023 Nov 7;164:28-38. doi: 10.1016/j.molimm.2023.10.011. Epub ahead of print. PMID: 37944204.

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