B-hPD-L1/hTIM3 mice

May 22, 2019

PD-L1 (Programmed cell death ligand-1), also known as B7-H1 and CD274, is mainly expressed in antigen-presenting cells (APCs) and activated T cells, and is one of the two ligands of PD-1. The interaction between PD1 and PD-L1 plays an important role in the negative regulation of the immune response. PD-L1 is highly expressed in a […]

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B-hSIRPα/hCD47 mice

May 21, 2019

SIRPα (Signal-regulatory protein alpha) is a transmembrane protein widely expressed in myeloid cells , stem cells and neurons. Its extracellular part include 3 Immunoglobulinlike domains. SIRPα binds to its ligand CD47 through the variable IgV-like domains. CD47 is also widely expressed in multiple tissue cells. CD47+ cells activate SIRPα on macrophage surface to prevent its […]

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B-Oxr1-iCreERT2 Mice

May 21, 2019

The Oxr1 gene, encoding oxidation resistance 1, is a member of a conserved family of genes found in eukaryotes but not in prokaryotes. In this strain, Cre recombinase expression is under the control of Oxr1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest and treated with tamoxifen, Cre-mediated recombination results […]

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B-hPD-1/hSIRPA/hCD47 mice

May 21, 2019

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-1 interacts with its ligands and plays an important role in the negative regulation of the immune response. PD-L1 protein expression is detected in many […]

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B-Pdgfrb-iCre Mice

May 21, 2019

The Pdgfrb gene encodes a cell surface tyrosine kinase receptor, the beta- type platelet-derived growth factor receptor. In this strain, codon optimized Cre recombinase expression is under the control of Pdgfrb promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, iCre-mediated recombination results in deletion of the flanked sequence in Pdgfrb […]

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B-hPD-L1/hSIRPA/hCD47 mice

May 21, 2019

PD-L1 (Programmed cell death ligand-1), also known as B7-H1 and CD274, is mainly expressed in antigen-presenting cells (APCs) and activated T cells, and is one of the two ligands of PD-1. The interaction between PD1 and PD-L1 plays an important role in the negative regulation of the immune response. PD-L1 is highly expressed in a […]

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B-Prrx1-iCre Mice

May 21, 2019

The Prrx1 gene encodes a DNA-associated protein, paired related homeobox 1, localized to the nucleus and functions as a transcription coactivator. This protein regulates muscle creatine kinase, and differentiation of mesenchymal precursors. Prrx1 expression is restricted to the mesoderm during embryonic development and mesenchymal tissues in adult mice. In this strain, Cre recombinase expression is […]

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B-Apoa4 KO Rats

May 21, 2019

Apolipoprotein A4 is a plasma protein and synthesized in the intestine and liver. ApoA4 is secreted into circulation on the surface of newly synthesized chylomicron particles. The primary functions of ApoA4 have not been clearly established; however, ApoA4 has been implicated in regulating appetite and satiety in rodent models, modulating the lipid transport in vitro, […]

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B-Sp7 (Osx)-iCre Mice

May 21, 2019

The Sp7 gene is a C2H2-type zinc finger transcription factor of the SP gene family and putative master regulator of bone cell differentiation. In this strain, Cre recombinase expression is under the control of Sp7 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the […]

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