B-Gfap-iCre mice

September 23, 2020

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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B-Dcp2-iCreERT2 mice

September 23, 2020

Dcp2 encoded by Dcp2 gene. It is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5′ end. Alternatively spliced transcript variants encoding different isoforms have been noted […]

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B-Myh6-iCreERT2 mice

September 23, 2020

Myh6 gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

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B-Cdh5-iCreERT2 mice

September 23, 2020

Cdh5 gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of […]

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B-Cam1(Mcpt5)-iCre mice

September 23, 2020

Cma1 gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. The encoded preproprotein undergoes proteolytic processing to generate a functional enzyme with elastase-like […]

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B-Tex264-iCre-EGFP mice

September 23, 2020

Tex264 gene is located on mouse chromosome 9 and is mainly highly expressed in the kidney and adrenal gland of adult mice, and is also partially expressed in the other 28 tissues of mice. B-Tex264-IRES-iCre-GFP mice, as a cre tool mouse with 264 promoter-induced expression, achieve gene knockout of specific genes at specific times or […]

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