B-Apoa4 KO rats

May 21, 2019

The Apoa4 KO rat was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses an 8 bp deletion within Exon 2 on chromosome 8 causing a protein frame shift. This strain was maintained by mating homozygous males with homozygous females on a Sprague-Dawley genetic background.

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B-Sp7-iCre mice

May 21, 2019

The Sp7 gene is a C2H2-type zinc finger transcription factor of the SP gene family and putative master regulator of bone cell differentiation. In this strain, Cre recombinase expression is under the control of Sp7 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the […]

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