B-hPD1/hLAG3/hTIM3 mice

September 17, 2020

PD-1 (Programmed death-1) is mainly expressed on the surface of T cells and primary B cells. The two PD-1 ligands, PD-L1 and PD-L2, are widely expressed on antigen-presenting cells (APCs). PD-L1 expression is favorable for tumorigenesis and growth, for induction of anti-tumor T cell apoptosis, and for escaping responses by the immune system. Inhibition of […]

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B-hNKG2A mice

September 16, 2020

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. […]

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B-NDG B2m KO mice plus

July 24, 2020

Human PBMC-engrafted humanized mice are attractive models for in vivo analysis of human immune responses. We previously reported that human PBMCs could be engrafted in B-NDG mice successfully.However, because of severe xenogeneic graft versus host disease (xeno-GVHD) in these mice, there is a limited window for experimentation. This makes it difficult to analyze human immune […]

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B-hLAG3 mice plus

June 22, 2020

LAG3 (Lymphocyte activation gene 3, CD223) is a lymphocyte activation gene and a member of the Ig family. It is mainly expressed in activated T cells, NK cells, B cells and plasmacytoid DCs. LAG3 is a negative regulator of immunity and mainly binds to MHC class Ⅱ molecules to regulate the function of dendritic cells. […]

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B-hCD38 mice

June 22, 2020

CD38 is a 42 kD glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed on B cells, NK cells, a subset of T cells, brain, muscle, and kidney. In mouse, CD38 expression is downregulated on germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as […]

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B-hB7-H3 mice

June 22, 2020

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene and belongs to the immunoglobulin superfamily. The transcript of B7-H3 is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. B7H3 is expressed on immune cells (such as antigen-presenting cells or macrophages) and […]

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B-HLA-A2.1 Mice

June 22, 2020

Transgenic mice that express human HLA molecules represent a unique in vivo experimental model for evaluating human immune system function.These models have been used to study the role of the human class I or class Il restricted T cell repertoire in autoimmune disease, infectious disease, and vaccine development. They are also valued tools for evaluating […]

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B-hCCR4 mice

June 22, 2020

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). CCR4 belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2, CCL4, CCL5, CCL17, CCL22. Chemokines are a group of […]

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B-hCD73 mice

June 22, 2020

CD73 is expressed on the surface of multiple cells of the immune system including T-cells, B-cells, NK-cells and myeloid-derived suppressor cells. CD73 catalyzes the final hydrolysis of AMP to adenosine following CD39 activity. Increased expression of CD73 has been associated with several tumor signaling pathways stimulated by hypoxyia in the TME. Anti-CD73 therapy in combination […]

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B-hIL6/hIL6R mice

May 31, 2020

IL6 encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into […]

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