Rat Gene Editing

Among the most commonly used mammalian experimental animal models, rat models offer many advantages over the mouse and other organisms. 

The physiology of diseased rat models not only resembles more closely to that of humans but it is also comparatively easier to monitor in rats than mice. Popular experimental rat model strains include Sprague Dawley, Wistar, and F344. Biocytogen’s transgenic rat service uses CRISPR/Cas9-based EGE™ to generate gene knockout and knockin rat models.

Transgenic Rat Service Application Example:

The First Reporter Knockin Rat Developed by Biocytogen in 2014

As shown below, a pCAG-loxP-3X STOP-loxP-tdTomato-WPRE-bGHpA cassette is inserted between the first and second exons of the Rosa26 site using EGE™ technology. After mating cKI rats with Crh-Cre rats, tdTomato is highly expressed in the hippocampus of the Crh-Cre/tdTomato offspring.

Cre Rat Models List

Product Product No Application Fields
B-Drd2-Cre Rats 210488 Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)
B-Oxt-iCre rats 210501 Oxt promoter-driven Cre rat model (hypothalamus;)

Other Genetically Modified Rat Models

Product Product No Description and Application
B-Apoe KO rats 210508 Cardiovascular system (hyperlipidemia, atherosclerosis)
B-IL2rg KO rats 210513 Immune system (Immunodeficiency)
B-Ldlr KO rats 210506 Cardiovascular system (Hyperlipidemia, atherosclerosis)
B-Pink1 KO rats 210509 Parkinson disease model
B-Rag2 KO rats 210511 Immune system (Immunodeficiency)
B-Rag2/IL2rg KO rats 210512 Immune system (Immunodeficiency)
B-p53 KO rats 210507 Tumor formation, drug detection