Among the most commonly used mammalian experimental animal models, rat models offer many advantages over the mouse and other organisms.
The physiology of diseased rat models not only resembles more closely to that of humans but it is also comparatively easier to monitor in rats than mice. Popular experimental rat model strains include Sprague Dawley, Wistar, and F344. Biocytogen’s transgenic rat service uses CRISPR/Cas9-based EGE™ to generate gene knockout and knockin rat models.
Transgenic Rat Service Application Example:
The First Reporter Knockin Rat Developed by Biocytogen in 2014
As shown below, a pCAG-loxP-3X STOP-loxP-tdTomato-WPRE-bGHpA cassette is inserted between the first and second exons of the Rosa26 site using EGE™ technology. After mating cKI rats with Crh-Cre rats, tdTomato is highly expressed in the hippocampus of the Crh-Cre/tdTomato offspring.
Cre Rat Models List
|Product||Product No||Application Fields|
|B-Drd2-Cre Rats||210488||Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)|
|B-Oxt-iCre rats||210501||Oxt promoter-driven Cre rat model (hypothalamus;)|
Other Genetically Modified Rat Models
|Product||Product No||Description and Application|
|B-Apoe KO rats||210508||Cardiovascular system (hyperlipidemia, atherosclerosis)|
|B-IL2rg KO rats||210513||Immune system (Immunodeficiency)|
|B-Ldlr KO rats||210506||Cardiovascular system (Hyperlipidemia, atherosclerosis)|
|B-Pink1 KO rats||210509||Parkinson disease model|
|B-Rag2 KO rats||210511||Immune system (Immunodeficiency)|
|B-Rag2/IL2rg KO rats||210512||Immune system (Immunodeficiency)|
|B-p53 KO rats||210507||Tumor formation, drug detection|