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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

Punit Upadhyaya1, Johanna Lahdenranta1, Kristen Hurov1, Sailaja Battula1, Rachel Dods2, Eric Haines1, Marianna Kleyman1, Julia Kristensson2, Jessica Kublin1, Rachid Lani2, Jun Ma1, Gemma Mudd2, Elizabeth Repash1, Katerine Van Rietschoten2, Tom Stephen1, Fanglei You1, Helen Harrison2, Liuhong Chen2, Kevin McDonnell1, Philip Brandish1 and Nicholas Keen1

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B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes

You G, Lee Y, Kang YW, Park HW, Park K, Kim H, Kim YM, Kim S, Kim JH, Moon D, Chung H, Son W, Jung UJ, Park E, Lee S, Son YG, Eom J, Won J, Park Y, Jung J, Lee SW. B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes. Sci Adv. 2021 Jan 15;7(3):eaax3160. doi: 10.1126/sciadv.aax3160. PMID: 33523913; PMCID: PMC7810375.

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