ATG-101 is a tetravalent PD-L1×4-1BB bispecific antibody that stimulates anti-tumor immunity through PD-L1 blockade and PD-L1-directed 4-1BB activation Used in this study: B-h4-1BB mice Read more
Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model Used in this study: B-Il17a-EGFP mice Read more
A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity Used in this study: B-hPD-1/hPD-L1 mice Read more
p53 promotes antiviral innate immunity by driving hexosamine metabolism Used in this study: B-p53 KO mice Read more
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution Used in this study: Immunodeficient B-NDG Mice Read more
GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy Used in this study: B-hIL4/hIL4RA mice(C.B6) Read more
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery Used in this study: B-hTFR1 mice Read more
EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors Used in this study: B-hEPCAM mice, B-NDG mice Read more
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1 Used in this study: B-Cx3cr1-iCreERT2-EGFP mice Read more
ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1 Used in this study: B-h4-1BB mice Read more