The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies Used in this study: B-h4-1BB mice Read more
Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization Used in this study: B-Cdh5-iCreERT2 mice Read more
PPFIA1-targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration Used in this study: Immunodeficient B-NDG Mice Read more
Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia Used in this study: Immunodeficient B-NDG Mice Read more
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours Used in this study: B-NDG B2m KO Mice Plus Read more
A new NASH model in aged mice with rapid progression of steatohepatitis and fibrosis Used in this study: C57BL/6 mice Read more
Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells Used in this study: B-p53 KO mice Read more
Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Rα, for the treatment of Th2 inflammatory diseases Used in this study: B-hIL4/hIL4RA mice Read more
Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model Used in this study: B-Il17a-EGFP Mice Read more
Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane Used in this study: B-NDG Mice Read more
