Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference Used in this study: Gene Editing Services Read more
A new NASH model in aged mice with rapid progression of steatohepatitis and fibrosis Used in this study: C57BL/6 mice Read more
Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2 Used in this study: Gene Editing Services Read more
Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells Used in this study: B-p53 KO mice Read more
Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade Used in this study: Gene Editing Services Read more
Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Rα, for the treatment of Th2 inflammatory diseases Used in this study: B-hIL4/hIL4RA mice Read more
Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model Used in this study: B-Il17a-EGFP Mice Read more
Integrin CD11b Negatively Regulates B Cell Receptor Signaling to Shape Humoral Response during Immunization and Autoimmunity Used in this study: Gene Editing Services Read more
Knockout of Selenoprotein V Affects Regulation of Selenoprotein Expression by Dietary Selenium and Fat Intakes in Mice Used in this study: Gene Editing Services Read more
Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane Used in this study: B-NDG Mice Read more