The molecular biological mechanism of tanshinone VI on the treatment of the myocardium diseases
The tanshinone VI (the structure is shown in Figure 1) has recently attract various attentions because it is very effective for the clinical angina pectoris. In this paper, the molecular biological mechanism of its influence on the regulation of PLM to the ion channels as well as the hormone level was investigated by Western blotting method. The cardiac muscle cells were cultured with tanshinone VI in different environments and then transfected by PLMpAdtract. The overexpression of phosphorylation sites were analyzed by Western blotting. The results show that the tanshinone VI could efficiently affect the phosphorylation of Ser68 and Ser63. Moreover, in harsh conditions, the tanshinone VI could simultaneously restrain the expression of ERK 1/2 and increase the expression of phosphorylated Survivin. As a result, in the oxygen deprivation and glucose deprivation conditions, tanshinone VI is not only benefit to the myocardial contractive power via affecting the ion channels, but also to the enhancement of the cell survive via affecting the hormone protein expression.
Authors: Xiangfei Feng, Kai Guo, Wei Li, Jian Sun, Pengpai Zhang, Yigang Li
Influence Factor: 1.7059
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