Surrogate Feeding and Breeding of Mice

Relying on Biocytogen’s Haimen Animal Center, we can breed inbred mice, outbred mice, immune checkpoint mice, and cytokine humanized mice; these techniques can be further combined with Biocytogen’s gene editing platform (including F0 breeding of animal models, breeding of chimeric mice for ES gene targeting study, and F1 breeding) and IVF platform; thereby we can optimize animal use and cage space to offer more complex and more efficient breeding protocols to meet the client’s request for surrogate feeding.

Specification for Surrogate Mouse Feeding and Breeding

Acceptance Criteria for Parental Mice

  • Parental mice to be supplied by the client: 3–5 fertile male mice.
  • Documents to be filled out by the client: Genotype identification protocol for mice to be fed in surrogation.

Delivery Specification for Surrogate Mouse Feeding and Breeding

  • Quantity of delivered mice: Depending on the customer’s target.
  • Genotype of delivered mice: Depending on the customer’s target.
  • Microbial level of delivered mice: Tested negative for all 45 CRL tests (See Table 3).
  • Delivery period: the contract period agreed upon by both parties as per the surrogate feeding protocol;
  • Accompanying documents submitted at the time of mouse delivery: 1. Mouse genotype identification report. 2. Microbial testing report for mice (An analysis report for corresponding tests will be provided upon request of the client, and testing cost will be charged separately depending on test specifics).
No. Test Item
1 Salmonella spp.
2 Corynebacterium kutscheri
3 Pasteurella pneumotropica
4 Klebsiella pneumoniae
5 Staphylococcus aureus
6 Pseudomonas aeruginosa
7 Ectoparasites
8 Ectromelia Virus
9 Mouse Hepatitis Virus (MHV)
10 Sendai Virus
11 Pneumonia Virus of Mice (PVM)
12 Reovirus 3 (Reo 3)
13 Minute Virus of Mice
14 Clostridium piliforme
15 Lymphocytic Choriomeningitis Virus
16 Hantaan Virus
17 Mouse Encephalomyelitis Virus(GDVII)/Rat Theilovirus (RTV)
18 Mouse Adenovirus I and II (FL and K88)
19 Polyoma Virus
20 Streptococcus pneumoniae
21 Encephalitozoon cuniculi
22 Beta hemolytic Streptococcus (non-Group D)
23 Mycoplasma spp
24 Mycoplasma Pulmonis
25 Enteric Helminths
26 Endoparasites
27 Ciliates
28 Toxoplasma
29 Bordetella bronchiseptica
30 Pasteurella multocida
31 Klebsiella oxytoca
32 Citrobacter rodentium
33 Proteus spp.
34 Mouse Parvovirus (MPV)
35 Murine Norovirus (MNV)
36 Mouse Rotavirus (EDIM)
37 K Virus
38 Mouse Cytomegalovirus (MCMV)
39 Cilia Associated Respiratory Bacillus
40 Thymic Virus
41 Lactate Dehydrogenase Elevating Virus
42 Helicobacter spp.
43 Streptococcus B-hemolytic (Groups B)
44 Streptococcus B-hemolytic (Groups G)
45 NS-1

 

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