Tag: reconstitution

B-NDG hIL15 Mice: Where Enhanced Human Immune Reconstitution Fuels NK-Dependent Therapies

February 3, 2025

Highly immunodeficient mouse models enable human immune system reconstitution, allowing the engraftment of human tissues or cells for research on immune function, therapeutic efficacy, and disease modeling. While these models effectively reconstitute human T cells, the lack of human IL15—an essential cytokine for NK cell maturation—hinders human NK cell reconstitution, limiting research on NK cell […]

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