Advancing T cell Therapies Using B-hCD3 Mouse Models

Advancing T cell Therapies Using B-hCD3 Mouse Models

Speaker: John Charpentier, PhD, Business Development Manager, Biocytogen Boston

  • Translational challenges in immunotherapy impede the successful transition of many therapeutic candidates to the clinic
  • Biocytogen’s humanized mice are rigorously designed and validated in the following ways to improve translation of CD3-targeting candidates: Expression (mRNA & flow cytometry), Immune cell frequency & maturation profiling and functional validation using reference antibodies whenever available
  • Humanized mice allow for robust preclinical modeling/testing for novel CD3-targeting therapies, including: Mono-and bispecific antibody candidates, Novel combination therapies, Preliminary toxicity assessments

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