Application of HLA-Humanized Mice in Preclinical Research
Speaker: Dr. Leila Kokabee
Associate Director, In Vitro/Ex Vivo/Flow Cytometry Platform Leader
HLA (Human Leukocyte Antigen) genes are critical components of the immune system, enabling it to distinguish between the body’s own cells and foreign invaders. Variations in HLA genes affect immune responses and influence susceptibility to autoimmune diseases, making them essential targets in immunology research.
In this webinar, Dr. Leila Kokabee will explore the function of HLA genes and their applications in preclinical research, with a special focus on Biocytogen’s HLA-humanized mice. These models incorporate human HLA genes into mice, allowing for a more precise evaluation of drug efficacy, immunogenicity, and toxicity in a human-relevant immune context. HLA-humanized mice are essential for preclinical testing of immune therapies, including cancer immunotherapy and vaccines, and provide insights that are highly translatable to human studies. Their use accelerates drug development by allowing researchers to assess human-like responses before clinical trials.
Key Topics Include:
- The role of HLA genes in immune response and their significance in preclinical research.
- How Biocytogen’s HLA-humanized mice incorporate human HLA genes for more precise testing of drug efficacy and safety.
- Applications of HLA-humanized mice in various fields, including immunotherapy development, vaccine research, autoimmune disease modeling, and more.
