Webinar Humanized Animal Models

Preclinical Models to Investigate NK Cell-Targeted Immunotherapies

September 2, 2022

Speaker: Jenna Frame, Ph.D.  Manager, Scientific Communications & Marketing, Biocytogen Boston Reviewed the mechanisms driving NK cell activity in the context of immuno-oncology, and the types of NK-targeted immunotherapies currently under investigation Introduced experimental models used to evaluate these immunotherapies, including syngeneic models and xenograft models 

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Next-Generation B-NDG Mice: Improved Immunodeficient Models for Research and Discovery

June 24, 2022

Speaker: John Charpentier, Ph.D, Business Development Manager, Biocytogen Boston Introduced Biocytogen’s highly immunodeficient B-NDG mouse model Discussed our latest, next-generation B-NDG-derived models, such as the B-NDG β2m KO, B-NDG HLA-A2.1, and B-NDG hSIRPα/hCD47 models Described how B-NDG models recapitulate critical aspects of human biology, making them a powerful tool for biomedical research

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Mouse Models to Investigate New Treatments for Inflammatory Disease

January 27, 2022

Speaker: Jenna Frame, Ph.D.  Manager, Scientific Communications & Marketing, Biocytogen Boston Introduced immune system, cytokines, and autoimmune diseases. Reviewed Modeling Inflammatory Diseases in Wild-Type and Humanized Mice, including multiple Sclerosis/EAE, Rheumatoid Arthritis and Colitis/Inflammatory Bowel Disease. Inflammatory & autoimmune diseases have complex etiologies and mechanisms, but can be modeled in mice. We have established protocols […]

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Investigating Inflammatory Disease using Humanized Cytokine Mice

December 2, 2021

Speaker: Clarke Gasper, Ph.D. Senior Business Development Manager, Biocytogen Boston We reviewed the range of cytokines associated with various autoimmune and allergy related diseases. Introduced various humanized cytokine mouse models that can be used in disease modeling. The inflammatory disease models we have developed includes asthma, atopic dermatitis, and psoriasis. Details of some typical readouts […]

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Advancing T cell Therapies Using B-hCD3 Mouse Models

November 4, 2021

Biocytogen’s humanized mice are rigorously designed and validated in the following ways to improve translation of CD3-targeting candidates: Expression (mRNA & flow cytometry), Immune cell frequency & maturation profiling and functional validation using reference antibodies whenever available.

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Humanized Animal Models for Immunotherapy

October 2, 2020

Development and application of humanized animal models, which mimic human immunity and therapeutic targets, may provide promising solution to the challenges of preclinical translation

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