B-NDG hCSF1 mice

NOD.CB17-Prkdcscid Il2rgtm1Bcgen Csf1tm1(CSF1)Bcgen/Bcgen • 110591

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B-NDG hCRBN mice
B-NDG hCSF1/hTHPO mice

B-NDG hCSF1 mice

Catalog Number: 110591
Strain Name: NOD.CB17-Prkdcscid Il2rgtm1Bcgen Csf1tm1(CSF1)Bcgen/Bcgen
Strain Background: B-NDG
NCBI gene ID: 1435 (Human)
Aliases: op; Csfm; MCSF; BAP025; PG-M-CSF; Mhdabap25
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B-NDG hCSF1 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-NDG hCSF1 mice. The full sequences of mouse Csf1 genes except the UTRs were respectively replaced with the coding sequences (CDS) of human CSF1 gene.

      Protein expression analysis in spleen

      Strain specific CSF1 expression analysis in B-NDG mice and homozygous B-NDG hCSF1 mice by ELISA. Spleens were collected from B-NDG mice and homozygous B-NDG hCSF1 mice stimulated with 100 μg/mL LPS in vivo for 2 hrs (200 μL/mouse). Grinding supernatant from the spleens was analyzed by ELISA. Mouse CSF1 was only detectable in B-NDG mice. Human CSF1 was exclusively detectable in homozygous B-NDG hCSF1 mice. Values are expressed as mean ± SEM.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-NDG hCSF1 mice] (Cat# 110591) was purchased from Biocytogen.