Fully Human Antibody / TCR Platforms

Bispecific Antibody

Bispecific antibodies (BsAbs) offer unique advantages by targeting two antigens simultaneously, enabling enhanced specificity, overcoming resistance, and addressing disease heterogeneity. They optimize pharmacokinetics, reduce off-target effects, and support diverse mechanisms such as pathway blockade and immune cell redirection, unlocking broad therapeutic potential.
  • The ability to simultaneously target multiple tumor-driven proteins, potentially overcoming drug resistance.
  • Recognition of cells co-expressing both targets to increase tumor specificity and reduce off-target toxicity.
  • The combination of two selected targets increases internalization and thus tumor killing.
  • 10+
    Fully-human BsAbs
  • 10+
    TCR mimic Assets
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  • Advantages of Biocytogen's BsAb Platform
  • Discovery of Novel Bispecific Antibodies
  • Off-the-shelf BsAbs Available for Partnership

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      Advantages of Biocytogen's BsAb Platform
      • Versatile Design: Enables the assembly of diverse components like scFv, peptides, VHHs, and cytokines with flexible formats supported by technologies like Knobs-into-Holes.
      • Common Light Chain Advantage: Produces fully human common light chain antibodies for efficient and precise bispecific assembly with minimal mispairing.
      • High-Quality Antibodies: Combines RenLite KO mice and Beacon technology to generate antibodies with exceptional diversity and affinity.
      • Scalable Validation: Employs a robust in vivo system to identify effective and safe target combinations.
      • Bifunctional Molecules: Develops antibody-cytokine molecules with superior synergy, enhancing the druggability of cytokine-based therapies.
      Biocytogen's RenLite-based BsAb Platform

      BsAb developed from RenLite mice

      BsAb developed from RenLite mice
      Off-the-shelf BsAbs Available for Partnership
      Therapeutic Area Target(s) Immunization
      • Development
      • Hits
        selection         Leads
        selection         Candidate
        selection
      		Preclinical IND Status
      oncology OX40 x CTLA4 (YH006)
      oncology 4-1BB xCD40 (BCG021)
      oncology CD70xEGFR (BCG020)
      oncology CTLA4 X TNFR2
      Inflammation and Autoimmunity 0X40 x 0X40 (BcG028)