By Therapeutic Area

Neuroscience

Biocytogen has developed a series of genetically engineered mouse models and neurological disease models, including Alzheimer's Disease (AD) , Aging & Inflammation, Pain and Migraine, Amyotrophic lateral sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Autism spectrum disorders (ASD) models. A comprehensive behavioral testing platform has also been established to support preclinical drug development.
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  • Neurological Disease Model Introduction
  • Neuroscience Disease Models
  • Case Studies

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    Neurological Disease Model Introduction
    Central nervous system (CNS)-related diseases encompass a wide range of conditions, including cerebrovascular disorders, neurodegenerative diseases, immune-mediated disorders, and others. In clinical practice, these diseases are also classified based on their anatomical location, such as brain disorders, spinal cord disorders, peripheral nerve disorders, and neuromuscular disorders. In recent years, the incidence of CNS diseases has steadily increased with rising life expectancy, and they are now widely recognized as a major global health concern.
    Animal models are indispensable tools in CNS disease research, given the complexity and heterogeneity of these conditions. They help to investigate the underlying pathological and molecular mechanisms, identify potential biomarkers, evaluate the efficacy of therapeutic interventions, and provide preliminary assessments of the safety and effectiveness of drug candidates in humans.
    Neuroscience Disease Models
    Alzheimer's Disease (AD) Models
    Alzheimer's Disease (AD) Models
    Alzheimer's disease, the most common cause of dementia, is a progressive and irreversible neurodegenerative disorder that gradually impairs cognitive functions such as memory, reasoning, and behavior.
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    Aging & Inflammation Models
    Aging & Inflammation Models
    Biocytogen's aged mice and behavioral platform support research related to aging and inflammation.
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    Pain and Migraine Models
    Pain and Migraine Models
    Pain models include acute pain, inflammatory pain, neuropathic pain, migraine models, etc.
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    Amyotrophic lateral sclerosis (ALS) Models
    Amyotrophic lateral sclerosis (ALS) Models
    Biocytogen's animal models and behavioral research platform support studies related to amyotrophic lateral sclerosis (ALS).
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    Duchenne Muscular Dystrophy (DMD) Models
    Duchenne Muscular Dystrophy (DMD) Models
    Biocytogen's animal model and behavioral research platform supports studies related to duchenne muscular dystrophy (DMD).
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    Autism spectrum disorders (ASD) Models
    Autism spectrum disorders (ASD) Models
    Biocytogen's animal model and behavioral research platform supports studies related to autism spectrum disorder (ASD).
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    Schizophrenia Models
    Schizophrenia Models
    Biocytogen's animal model and behavioral research platform supports studies related to Schizophrenia.
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    Behavior Testing Platform in Biocytogen

    Biocytogen's Behavior Testing Platform offers comprehensive in vivo assessments of neurological and psychiatric functions, supporting drug discovery and disease research with advanced behavioral analysis.

    case study 1
    Behavior Testing Platform in Biocytogen

    Biocytogen has built a behavioral testing platform, including exercise and fatigue (rotarod , grip strength, beam balance, etc.), anxiety (open field, elevated maze), cognition (fear conditioning, barnes maze, Y-maze, novel object recognition , etc.), and perception (Vonfrey, hot-cold plates, scratching, etc.) tests, which can support preclinical efficacy studies in the fields of neuroscience and brain science.

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    Behavior Testing Platform in Biocytogen
    Product Name Product No. Background Action
    B-Abca7*V1613M mice 114002 C57BL/6JNifdc
    B-App NL-F mice 112976 C57BL/6JNifdc
    B-App NL-F/Psen1*E120K*M146L mice 113247 C57BL/6JNifdc
    B-App NL-F/Psen1*P117L mice 113345 C57BL/6JNifdc
    B-App NL-G-F mice 113062 C57BL/6JNifdc
    B-Cacng1 KO mice 114401 C57BL/6JNifdc
    B-Dmd KO(del45-50) mice 113915 C57BL/6JNifdc
    B-Dmd KO(del52) mice 114076 C57BL/6JNifdc
    B-Fabp4 KO mice 115342 C57BL/6JNifdc
    B-Fmr1 KO mice 112852 C57BL/6N
    B-Fus KO mice 170629 C57BL/6JNifdc
    B-Gdf8 KO mice 114424 C57BL/6JNifdc
    B-Glut1 KO mice 114552 C57BL/6JNifdc
    B-Grn KO mice 112567 C57BL/6N
    B-hACAT1 mice 113405 C57BL/6
    B-hACVR2A mice 111393 C57BL/6
    B-hAGT/hAPOC3 mice 113578 C57BL/6
    B-hAMIGO2 mice 111658 C57BL/6N
    B-hAPOE3*R136S mice 114313 C57BL/6JNifdc
    B-hAPOE3/hTFR1 mice 114082 C57BL/6
    B-hAPOE4 mice 112564 C57BL/6JNifdc
    B-hAPOE4/hCD98HC mice 114885 C57BL/6
    B-hAPOE4/hTFR1 mice 113663 C57BL/6
    B-hAPP mice 114197 C57BL/6JNifdc
    B-hAPP*K670N*M671L*V717I mice 113380 C57BL/6JNifdc
    B-hC1Q mice 111990 C57BL/6
    B-hC1S mice 112836 C57BL/6
    B-hC5AR1 mice 110078 C57BL/6
    B-hCACNG1 mice 113868 C57BL/6JNifdc
    B-hCALCRL mice 110115 C57BL/6
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