RenMice-Drug Discovery Engine

RenTCR mimic™

TCR mimic antibodies (TCRm) combine antibody stability with TCR specificity, targeting MHC-presented peptides with high precision. They offer broad applications in cancer, infections, and autoimmune diseases, advancing precision immunotherapy.
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  • Key Features of RenTCR mimic
  • Validation Data

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    Key Features
    1. RenTCR-mimic-derived fully human TCR mimic Antibodies showed high diversity
    RenTCR-mimic-derived fully human TCR mimic Antibodies showed high diversity RenTCR-mimic-derived fully human TCR mimic Antibodies showed high diversity 2
    2. RenTCR-mimic-derived fully human TCR mimic Antibodies showed high specificity
    Antigen specific action

    In vitro affinity-matured TCR nonspecifically activated by off-target peptides bound to HLA-A2.
    REGENERON, WO2020086647A1

    Target peptide NY-ESO1 SLLMWITQC
    Potential off-target peptide EARS2 SLLDIITNC
    MAGEH1 SLLMSILAL
    FBXL22 LLTMHITQL
    URB1 SLLTWILHI
    pHLA overexpressing cells
    Validation Data
    Validation Data img
    Validation Data img 2