B-Il17a-EGFP mice

Basic Information

Targeting Strategy

Details

Genotyping Information

Primer	Sequence (5’-3’)	Tm (℃)	Product size (bp)
Il17a EGFP primer 1	AAGCTGGACCACCACATGA	62	WT: 264
Il17a EGFP primer 2	TGAATCCACATTCCTTGCTG	62
Il17a EGFP primer 1	AAGCTGGACCACCACATGA	62	Mut: 390
Il17a EGFP primer 3	GACATTCAACAGACCTTGCATTC	62

Polymerase: Taq

Publications

Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model

Ramesh Kudira, Zi F Yang, Immaculeta Osuji, Rebekah Karns, Priya Bariya, Liva Pfuhler, Mary Mullen, Amy Taylor, Hong Ji, Celine S Lages, Annika Yang vom Hofe, Tiffany Shi, Srikar Pasula, Joseph A Wayman, Anas Bernieh, Wujuan Zhang, Claire A Chougnet, David A Hildeman, Gregory M Tiao, Stacey S Huppert, Sanjay Subramanian, Nathan Salomonis, Emily R Miraldi, Alexander G Miethke bioRxiv 2024.05.17.594680;

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

MicroRNAs -122 and -1247 restrain the pathogenicity of effector CD4+ T cells in autoimmune inflammation

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells

References

1. Colpitts SL; Puddington L; Lefrancois L. 2015. IL-15 receptor alpha signaling constrains the development of IL-17 producing gammadelta T cells. Proc Natl Acad Sci U S A 112(31):9692- 7. [PubMed: 26195801]
2.Taylor PR; Roy S; Leal SM Jr; Sun Y; Howell SJ; Cobb BA; Li X; Pearlman E. 2014.
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2. Nat Immunol 15(2):143-51. [PMID:
24362892]
3. Goto Y; Panea C; Nakato G; Cebula A; Lee C; Diez MG; Laufer TM; Ignatowicz L; Ivanov
II. 2014. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40(4):594-607. [PMID: 24684957]
4. Duhen R; Glatigny S; Arbelaez CA; Blair TC; Oukka M; Bettelli E. 2013. Cutting Edge: The Pathogenicity of IFN-gamma-Producing Th17 Cells Is Independent of T-bet. J Immunol 190(9):4478-82. [PMID: 23543757]
5. Lee Y; Awasthi A; Yosef N; Quintana FJ; Xiao S; Peters A; Wu C; Kleinewietfeld M; Kunder S; Hafler DA; Sobel RA; Regev A; Kuchroo VK. 2012. Induction and molecular signature of pathogenic T(H)17 cells. Nat Immunol 13(10):991-9. [PMID: 22961052]