Basic Information

Strain Name
C57BL/6-Gdf15tm1(GDF15)/Bcgen
Common Name
B-hGDF15 mice
Background
C57BL/6
Catalog Number
111201
Related Gene
growth differentiation factor 15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hGDF15 mice.

The exons 1-2 of mouse Gdf15 gene that encode the full-length protein were replaced by human GDF15 exons 1-2 in B-hGDF15 mice.

Protein expression analysis

Species-specific GDF15 expression analysis in homozygous B-hGDF15 mice. Serum was collected from wild-type (+/+) and B-hGDF15 (H/H) mice and analyzed using a species-specific GDF15 ELISA kit. Mouse GDF15 expression was detectable in wild-type mice, while human GDF15 expression was exclusively detectable in B-hGDF15 (H/H) mice compared to wild-type.