Basic Information

Strain Name
C57BL/6-Gdf15tm1(GDF15)/Bcgen
Common Name
B-hGDF15 mice
Background
C57BL/6
Catalog Number
111201
Related Gene
growth differentiation factor 15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hGDF15 mice.

The exons 1-2 of mouse Gdf15 gene that encode the full-length protein were replaced by human GDF15 exons 1-2 in B-hGDF15 mice.

Protein expression analysis

Strain specific GDF15 expression analysis in heterozygous B-hGDF15 mice by ELISA.

Serum was collected from C57BL/6 wild-type mice (+/+)  and heterozygous B-hGDF15 mice (H/+) analyzed by ELISA with species-specific GDF15 ELISA kit. Mouse GDF15 were both detectable in wild-type mice and heterozygous B-hGDF15 mice. Human GDF15 was exclusively detectable in heterozygous B-hGDF15 mice but not in wild-type mice. ND: not detected.