B-hHER3 mice

C57BL/6-Erbb3tm1(ERBB3)Bcgen/Bcgen • 110791

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B-hHER2/hTROP2 mice
B-hHER3 rats

B-hHER3 mice

Catalog Number: 110791
Strain Name: C57BL/6-Erbb3tm1(ERBB3)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 2065 (Human)
Aliases: HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
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B-hHER3 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hHER3 mice. The exons 1-17 of mouse Her3 gene that encode the extracellular domain and transmembrane domain were replaced by human HER3 exons 1-17 in B-hHER3 mice.

      mRNA expression analysis

      Strain specific analysis of HER3 gene expression in wild type (WT) mice and B-hHER3 mice by RT-PCR. Mouse Her3 mRNA was detectable only in liver of WT mice (+/+). Human HER3 mRNA was detectable only in homozygous B-hHER3 mice (H/H) but not in WT mice (+/+).

      IHC analysis of HER3 expression

      Immunohistochemical (IHC) analysis of HER3 expression in homozygous B-hHER3 mice. The liver and colon were collected from WT and homozygous B-hHER3 mice (H/H) and analyzed by IHC with anti-HER3 antibody. HER3 was detectable in WT mice and homozygous B-hHER3 mice due to the cross-reactivity of the antibody. The arrow indicates tissue cells with positive HER3 staining (brown).

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hHER3 mice] (Cat# 110791) was purchased from Biocytogen.