mRNA expression analysis:
Mouse Cd36 mRNA was detected in lung tissue isolated from wild-type mice, while human CD36 mRNA was detected in homozygous B-hCD36 mice.
Human CD36 protein was detected in homozygous B-hCD36 mice, but not in wild-type mice.
CD36 humanization does not change the overall development, differentiation or distribution of spleen, lymph node, and blood immune cells in B-hCD36 mice.
Anti-CD36 mono- and combination therapy controlled MC38 tumor growth in B-hCD36 mice.