AACR 2023: Novel Humanized CD36 Mouse Model for Therapeutic Studies
Used in the poster: B-hCD36 mice
Conclusions
- mRNA expression analysis:
Mouse Cd36 mRNA was detected in lung tissue isolated from wild-type mice, while human CD36 mRNA was detected in homozygous B-hCD36 mice. - Protein expression analysis:
Human CD36 protein was detected in homozygous B-hCD36 mice, but not in wild-type mice. - Immune cell analysis:
CD36 humanization does not change the overall development, differentiation or distribution of spleen, lymph node, and blood immune cells in B-hCD36 mice. - In vivo efficacy of anti-CD36 antibodies:
Anti-CD36 mono- and combination therapy controlled MC38 tumor growth in B-hCD36 mice.
