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    AACR 2023: Novel Humanized CD36 Mouse Model for Therapeutic Studies

    April 18, 2023
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    Conclusions


    mRNA expression analysis:

    Mouse Cd36 mRNA was detected in lung tissue isolated from wild-type mice, while human CD36 mRNA was detected in homozygous B-hCD36 mice.


    Protein expression analysis:

    Human CD36 protein was detected in homozygous B-hCD36 mice, but not in wild-type mice.


    Immune cell analysis:

    CD36 humanization does not change the overall development, differentiation or distribution of spleen, lymph node, and blood immune cells in B-hCD36 mice.


    In vivo efficacy of anti-CD36 antibodies:

    Anti-CD36 mono- and combination therapy controlled MC38 tumor growth in B-hCD36 mice.

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