RenMice-Drug Discovery Engine

RenMab®

RenMab mice have complete human antibody heavy and light chain variable regions in situ replaced for the development of fully human monoclonal antibodies with high diversity, high affinity, and low immunogenicity.
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  • Key Features of RenMab
  • Validation Data

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    Key Features
    1. Full human heavy chain and kappa light chain V(D)J loci substitution in situ
    Heavy Chain
    2. Fully human antibody repertoire diversity
    Fully human antibody img Fully human antibody img 2
    3. Robust immune response comparable to wild-type mouse
    Immune response img Immune response img 2
    Validation Data

    The binding affinity of RenMab derived antibodies is comparable to antibodies generated from wild - type mouse and chimeric antibodies.

    Affinity to Antigen
    Spleen
    1. Spleen B Cell Development
    Spleen B Cell Development Bone Marrow B Cell Development