B-hEMP2 mice

C57BL/6-Emp2tm1(EMP2)Bcgen/Bcgen • 111358

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B-hEGFR/hMET/hHGF mice
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B-hEMP2 mice

Catalog Number: 111358
Strain Name: C57BL/6-Emp2tm1(EMP2)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 2013 (Human)
Aliases: XMP
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B-hEMP2 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hEMP2 mice. The exons 2-5 of mouse Emp2 gene that encodes the full-length protein was replaced by human EMP2 exons 2-5 in B-hEMP2 mice.

      mRNA expression analysis
      Strain specific analysis of EMP2 gene expression in wild-type C57BL/6 mice and B-hEMP2 mice by RT-PCR. Mouse Emp2 mRNA was detectable only in the lung of wild-type C57BL/6 mice (+/+). Human EMP2 mRNA was detectable only in homozygous B-hEMP2 mice (H/H), but not in wild-type mice.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hEMP2 mice] (Cat# 111358) was purchased from Biocytogen.