Basic Information

Strain Name
BALB/c-Ncr1tm1(NCR1)/Bcgen
Common Name
B-hNKP46 mice(C)
Background
BALB/c
Catalog Number
112004
Alias
CD335, LY94, NK-p46, NKP46, NCR1
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hNKP46 mice(C). Exons 1~7 of the mouse NKp46 gene that encodes the extracellular domain were replaced by human NKP46 exons 1~7 in B-hNKP46 mice(C).

Protein expression analysis

Species-specific NKP46 protein expression analysis in wild-type and humanized B-hNKP46 mice(C). Splenocytes were isolated from wild-type BALB/c (+/+) and heterozygous B-hNKP46 mice(C) (H/+), and analyzed by flow cytometry using species-specific anti-NKP46 antibodies. Mouse NKP46 protein was detected in wild-type and heterozygous mice, while human NKP46 protein was only detected in B-hNKP46 mice(C).

Species-specific NKP46 protein expression analysis in wild-type and humanized B-hNKP46 mice(C). Lymphocytes were isolated from wild-type BALB/c (+/+) and heterozygous B-hNKP46 mice(C) (H/+), and analyzed by flow cytometry using species-specific anti-NKP46 antibodies. Mouse NKP46 protein was detected in wild-type and heterozygous mice, while human NKP46 protein was only detected in B-hNKP46 mice(C).