Animal Models & Cell Lines

Cell Lines

Cell line engineering involves the targeted genetic modification of cell lines to understand how specific genetic alterations influence cellular function. This capability is critical for creating advanced research models, including humanized cell lines that express clinically relevant human targets. By examining the resulting phenotypic changes, researchers can better characterize disease biology and more effectively drive the discovery and development of new drugs and cancer therapies.

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  • Key Features of Biocytogen's Humanized Cell Lines
  • Featured Products
  • Product List
  • Gene Humanized Cell Lines
  • Mouse-Derived Cell Lines
  • Reporter Cell Lines
  • Point mutation cell line

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      Key Features of Biocytogen's Humanized Cell Lines
      Biocytogen leverages extensive gene-editing expertise to engineer high-performance humanized cell lines that accelerate oncology and immunotherapy research. Using advanced technologies such as EGE and ES, we develop humanized cell line models expressing key human immune checkpoint molecules (e.g., PD-L1), tumor-associated antigens (e.g., HER2, TROP2), and other immune-related targets. These models are designed to support research across a broad range of cancers, including colon cancer, melanoma, hepatocellular carcinoma, breast cancer, and additional solid tumor indications.
      By delivering reliable, well-characterized humanized cell line systems, Biocytogen supports more accurate evaluation of monoclonal antibodies, bispecific antibodies, polyclonal antibodies, tumor vaccines, ADCs, and other tumor immunotherapies. These advanced cell line models enhance preclinical screening efficiency and allow researchers to investigate human-specific target interactions.
      Featured Products
      Product List
        Gene Humanized Cell Lines
        Product Name Product No. Background Actions
        B-hADAM9 MC38 322015 C57BL/6
        B-hALB MC38 321909 C57BL/6
        B-hAMHR2 MC38 311530 C57BL/6
        B-hANXA2 MC38 321942 C57BL/6
        B-hAREG MC38 311648 C57BL/6
        B-hB2M/HLA-G MC38 321848 C57BL/6
        B-hB2M/HLA-G MC38 plus 322472 C57BL/6
        B-hB7-H3 B16-F10 322437 C57BL/6J
        B-hB7-H3 CT26.WT 321829 BALB/c
        B-hB7-H3 EL4 310705 C57BL/6N
        B-hB7-H3 LLC1 322470 C57BL/6
        B-hB7-H3 MC38 310704 C57BL/6
        B-hB7-H4 B16-F10 310909 C57BL/6
        B-hB7-H4 MC38 310726 C57BL/6
        B-hBCMA CT26.WT 322262 BALB/c
        B-hBCMA MC38 310720 C57BL/6
        B-hBCMA-luc EL4 321828 C57BL/6
        B-hBCMA/hGPRC5D MC38 322252 C57BL/6
        B-hc-MPL MC38 321998 C57BL/6
        B-hC5 MC38 311324 C57BL/6
        B-hCAIX MC38 322538 C57BL/6
        B-hCAXII MC38 321939 C57BL/6
        B-hCCL2 MC38 321866 C57BL/6
        B-hCCR4 MC38 310894 C57BL/6
        B-hCCR4-luc EL4 321851 C57BL/6
        B-hCCR9 MC38 321825 C57BL/6
        B-hCD10 MC38 321959 C57BL/6
        B-hCD106 MC38 321912 C57BL/6
        B-hCD112 MC38 321947 C57BL/6
        B-hCD151 MC38 321979 C57BL/6
        B-hCD155 MC38 310697 C57BL/6
        B-hCD19 EL4 310712 C57BL/6N
        B-hCD19 MC38 310706 C57BL/6
        B-hCD19-luc-GFP A20 322286 BALB/c
        B-hCD20 EL4 310717 C57BL/6N
        B-hCD20 MC38 310716 C57BL/6
        B-hCD200 MC38 321839 C57BL/6
        B-hCD24 MC38 311050 C57BL/6
        B-hCD36 MC38 311094 C57BL/6
        B-hCD37 MC38 310976 C57BL/6
        B-hCD38 MC38 310730 C57BL/6
        B-hCD38 MC38 plus 322551 C57BL/6
        B-hCD38-luc E.G7-OVA 311445 C57BL/6
        B-hCD39 MC38 311521 C57BL/6
        B-hCD47 CT26.WT 310702 BALB/c
        B-hCD47 MC38 310695 C57BL/6
        B-hCD47/hGPC3 MC38 322406 C57BL/6
        B-hCD56 MC38 321992 C57BL/6
        B-hCD73 MC38 310728 C57BL/6
        B-hCDH17 B16-F10 322270 C57BL/6
        B-hCDH17 MC38 321937 C57BL/6
        B-hCEACAM1 MC38 310690 C57BL/6
        B-hCEACAM5 MC38 322519 C57BL/6
        B-hCLDN18.2 A549 310791
        B-hCLDN18.2 BxPC-3 321827
        B-hCLDN18.2 MC38 310715 C57BL/6
        B-hCLDN6 MC38 311733 C57BL/6
        B-hCXCR2 MC38 310824 C57BL/6
        B-hCXCR4 MC38 310896 C57BL/6
        B-hCXCR5 MC38 311084 C57BL/6
        B-hDLL3 B16-F10 321826 C57BL/6
        B-hDLL3 CT26.WT 322414 BALB/c
        B-hDLL3 low B16-F10 322471 C57BL/6
        B-hDLL3 MC38 311448 C57BL/6
        B-hEFEMP1 MC38 321926 C57BL/6
        B-hEGFR*L858R*T790M MC38 322503 C57BL/6
        B-hENPP3 MC38 322250 C57BL/6
        B-hEPCAM B16-F10 322010 C57BL/6
        B-hEPCAM EL4 310713 C57BL/6N
        B-hEPCAM LLC1 322009 C57BL/6
        B-hEPCAM MC38 310708 C57BL/6
        B-hF3 MC38 311082 C57BL/6
        B-hFAP MC38 310825 C57BL/6
        B-hFGFR2IIIb MC38 322307 C57BL/6
        B-hFGL1 MC38 311270 C57BL/6
        B-hFN14 MC38 311053 C57BL/6
        B-hFOLR1 MC38 322242 C57BL/6
        B-hGAS6 MC38 321847 C57BL/6
        B-hGDF15 MC38 322371 C57BL/6
        B-hGPC3 CT26.WT 322261 BALB/c
        B-hGPC3 CT26.WT plus 322428 BALB/c
        B-hGPC3 MC38 plus 322039 C57BL/6
        B-hGPNMB MC38 322002 C57BL/6
        B-hGPRC5D MC38 321822 C57BL/6
        B-hGUCY2C B16-F10 322454 C57BL/6
        B-hGUCY2C MC38 321837 C57BL/6
        B-hHER2 B16-F10 322393 C57BL/6
        B-hHER2 CT26.WT 322200 BALB/c
        B-hHER2 EL4 310724 C57BL/6N
        B-hHER2 MC38 310701 C57BL/6
        B-hHER2 MC38 plus 322353 C57BL/6
        B-hHER2/hHER3 MC38 322535 C57BL/6
        B-hHER3 MC38 322045 C57BL/6
        B-hHRH3 MC38 321956 C57BL/6
        B-hHVEM MC38 310693 C57BL/6
        B-hIL34 MC38 321830 C57BL/6
        B-hIL8 MC38 322048 C57BL/6
        B-hITGA7 MC38 321929 C57BL/6
        B-hJAM3 MC38 322013 C57BL/6
        B-HLA-A11.1 MC38 322446 C57BL/6
        B-HLA-A11.1/hKRAS*G12D MC38 322455 C57BL/6
        B-HLA-A11.1/hKRAS*G12V B16-F10 322442 C57BL/6
        B-HLA-A11.1/hKRAS*G12V MC38 322409 C57BL/6
        B-HLA-A11.1/hKRAS*G12V Pan 02 322494
        B-HLA-A11.1/hMAGEA3 MC38 322398 C57BL/6
        B-HLA-A2.1 MC38 322407 C57BL/6
        B-HLA-A2.1/hAFP MC38 322402 C57BL/6N
        B-HLA-A2.1/hGP100 MC38 322400 C57BL/6N
        B-HLA-A2.1/hGPC3 MC38 322527 C57BL/6
        B-HLA-A2.1/hLMP2 MC38 322361 C57BL/6
        B-HLA-A2.1/hMAGEA3 MC38 322359 C57BL/6
        B-HLA-A2.1/hMAGEA4 MC38 322404 C57BL/6
        B-HLA-A2.1/hNY-ESO-1 MC38 322354 C57BL/6
        B-HLA-A2.1/hPRAME MC38 322453 C57BL/6
        B-HLA-A2.1/HPV16 E6/E7 MC38 322401 C57BL/6
        B-HLA-A2.1/hWT1 MC38 322362 C57BL/6
        B-HLA-A24.2 MC38 322451 C57BL/6
        B-HLA-E MC38 plus 311147 C57BL/6
        B-HLA-E plus/hPD-L1 MC38 322121 C57BL/6
        B-hLAIR1-luc EL4 311697 C57BL/6N
        B-hLILRB4 luc EL4 111915 C57BL/6
        B-hLILRB4 MC38 310815 C57BL/6
        B-hLRRC15 MC38 321867 C57BL/6
        B-hLRRN1 MC38 322195 C57BL/6
        B-hMERTK MC38 311600 C57BL/6
        B-hMET MC38 321957 C57BL/6
        B-hMMP-8 MC38 322005 C57BL/6
        B-hMSLN MC38 332181 C57BL/6
        B-hMUC1 MC38 311266 C57BL/6
        B-hMUC17 MC38 321918 C57BL/6
        B-hNECTIN4 MC38 310954 C57BL/6
        B-hOLFML3 MC38 321865 C57BL/6
        B-hPD-L1 B16-F10 310687 C57BL/6
        B-hPD-L1 CT26.WT 322204 BALB/c
        B-hPD-L1 EL4 310700 C57BL/6N
        B-hPD-L1 LLC1 310686 C57BL/6
        B-hPD-L1 low B16-F10 310890 C57BL/6
        B-hPD-L1 low MC38 310889 C57BL/6
        B-hPD-L1 MC38 310685 C57BL/6
        B-hPD-L1 MC38 plus 310699 C57BL/6
        B-hPD-L1 plus/hB7-H4 MC38 322422 C57BL/6
        B-hPD-L1 plus/hCD47 MC38 320714 C57BL/6
        B-hPD-L1 plus/hCDH6 MC38 322534 C57BL/6
        B-hPD-L1 plus/hCEACAM5 MC38 320722 C57BL/6
        B-hPD-L1 plus/hCLDN18.2 high MC38 322425 C57BL/6
        B-hPD-L1 plus/hCLDN18.2 MC38 322284 C57BL/6
        B-hPD-L1 plus/hDLL3 MC38 322420 C57BL/6
        B-hPD-L1 plus/hF3 MC38 322416 C57BL/6
        B-hPD-L1 plus/hFOLR1 MC38 322419 C57BL/6
        B-hPD-L1 plus/hGPC3 MC38 322418 C57BL/6
        B-hPD-L1 plus/hHER2 MC38 plus 322375 C57BL/6
        B-hPD-L1 plus/hPCSK9 MC38 322214 C57BL/6
        B-hPD-L1 plus/hROR1 MC38 322278 C57BL/6
        B-hPD-L1 plus/hROR1 MC38 plus 322427 C57BL/6
        B-hPD-L1 plus/hTPBG MC38 321835 C57BL/6
        B-hPD-L1 plus/hTROP2 low MC38 322283 C57BL/6
        B-hPD-L1 plus/Tg(hEGFR) MC38 322357 C57BL/6
        B-hPD-L1 plus/TROP2 MC38 322415 C57BL/6
        B-hPD-L1 Raji-luc 310684
        B-hPD-L1-Luc-EGFP LLC1 322483 C57BL/6
        B-hPD-L1/hB7-H3 MC38 321842 C57BL/6
        B-hPD-L1/hCD39 MC38 321831 C57BL/6
        B-hPD-L2 MC38 310703 C57BL/6
        B-hPTK7 MC38 322241 C57BL/6
        B-hROR1 CT26.WT 322263 BALB/c
        B-hROR1 MC38 310807 C57BL/6
        B-hSEZ6 B16-F10 322566 C57BL/6J
        B-hSEZ6 MC38 321944 C57BL/6
        B-hSIGLEC15 CT26.WT 322216 BALB/c
        B-hSIGLEC15 MC38 311049 C57BL/6
        B-hSLC39A6 MC38 322405 C57BL/6
        B-hSLC7A11/hSLC3A2 MC38 321850 C57BL/6
        B-hSPN MC38 322187 C57BL/6
        B-hSTEAP1 MC38 322199 C57BL/6
        B-hTNFR2 MC38 310723 C57BL/6
        B-hTPBG B16-F10 311265 C57BL/6
        B-hTPBG CT26.WT 322280 BALB/c
        B-hTPBG MC38 311068 C57BL/6
        B-hTROP2 CT26.WT 322202 BALB/c
        B-hTROP2 low MC38 311584 C57BL/6
        B-hUPAR MC38 311651 C57BL/6
        B-hVEGFA MC38 322309 C57BL/6
        B-hVEGFA/hPD-L1 B16-F10 322475 C57BL/6
        B-hVEGFA/hPD-L1 CT26.WT 322476 BALB/c
        B-hVEGFA/hPD-L1 plus MC38 322456 C57BL/6
        B-hVEGFA/hPD-L1/hEGFR MC38 322558 C57BL/6
        B-hVEGFA/hPD-L1/hTROP2 MC38 322549 C57BL/6
        B-Pembrolizumab-R-MC38 322501 C57BL/6
        B-Tg(hCCL1) MC38 321855 C57BL/6
        B-Tg(hCD70-EGFP) MC38 322364 C57BL/6
        B-Tg(hEGFR) MC38 322295 C57BL/6
        B-Tg(hHER2/hTROP2) MC38 321945 C57BL/6
        B-Tg(hMICA) MC38 321916 C57BL/6
        B-Tg(hPSMA) MC38 322488 C57BL/6
        B-Tg(hPSMA-Luc) PC-3 322459
        B-Tg(WT1 peptide-HLA-A2.1) MC38 322369 C57BL/6
        Mouse-Derived Cell Lines
        Product Name Product No. Background Actions
        B-mSiglec15 MC38 311529 C57BL/6
        B-Tg(mAbcb1b) MC38 322144 C57BL/6
        B-Tg(mAger) MC38 322163 C57BL/6
        B-Tg(mAlb) MC38 322093 C57BL/6
        B-Tg(mAmhr2) MC38 322152 C57BL/6
        B-Tg(mAreg) MC38 321898 C57BL/6
        B-Tg(mArtn) MC38 322092 C57BL/6
        B-Tg(mCar12) MC38 321899 C57BL/6
        B-Tg(mCcl2) MC38 322119 C57BL/6
        B-Tg(mCcr9) MC38 321896 C57BL/6
        B-Tg(mCd30) MC38 321906 C57BL/6
        B-Tg(mCd30l) MC38 322165 C57BL/6
        B-Tg(mCd70) MC38 321905 C57BL/6
        B-Tg(mCdh17) MC38 321864 C57BL/6
        B-Tg(mChil1) MC38 321877 C57BL/6
        B-Tg(mCldn2) MC38 321880 C57BL/6
        B-Tg(mEfemp1) MC38 322102 C57BL/6
        B-Tg(mEfna3) MC38 322159 C57BL/6
        B-Tg(mEgfr) MC38 321876 C57BL/6
        B-Tg(mEntpd2) MC38 322112 C57BL/6
        B-Tg(mEpha4) MC38 321873 C57BL/6
        B-Tg(mGpa33) MC38 321872 C57BL/6
        B-Tg(mGpc2) MC38 321889 C57BL/6
        B-Tg(mHpn) MC38 322110 C57BL/6
        B-Tg(mIgfbp2) MC38 321890 C57BL/6
        B-Tg(mIgfbp7) MC38 321891 C57BL/6
        B-Tg(mItga7) MC38 321922 C57BL/6
        B-Tg(mLrrn1) MC38 322076 C57BL/6
        B-Tg(mLypd3) MC38 322164 C57BL/6
        B-Tg(mMeltf) MC38 321893 C57BL/6
        B-Tg(mMet) MC38 321875 C57BL/6
        B-Tg(mMmp8) MC38 321892 C57BL/6
        B-Tg(mMpl) MC38 321888 C57BL/6
        B-Tg(mSez6) MC38 322160 C57BL/6
        B-Tg(mSez6l2) MC38 321882 C57BL/6
        B-Tg(mTff1) MC38 322115 C57BL/6
        Reporter Cell Lines
        Product Name Product No. Background Actions
        B-hPD-L1-Luc-EGFP LLC1 322483 C57BL/6
        B-Luc A-431 322225
        B-Luc A20 311118 BALB/c
        B-luc B16-F10 310680 C57BL/6
        B-Luc CT26.WT 322228 BALB/c
        B-luc Daudi 310677
        B-luc EL4 310682 C57BL/6
        B-Luc Hep 3B plus 310678
        B-Luc LLC1 321857 C57BL/6
        B-luc MIA PaCa-2 310674
        B-Luc THP-1 321919
        B-Luc-EGFP HL-60 321821
        B-Luc-EGFP SU-DHL-1 322063
        B-luc-GFP Raji 310670
        B-Tg(Luc) A549 321969
        B-Tg(Luc) HCT 116 321974
        B-Tg(Luc) LNCap Clone FGC 322217
        B-Tg(Luc) PC-3 321868
        B-Tg(Luc) RKO 321871
        B-Tg(Luc-EGFP) Hep G2 322408
        B-Tg(Luc-EGFP) NCI-H929 322373
        B-Tg(Luc-EGFP) U-87 MG 322265
        B16-F10-OVA 311537 C57BL/6
        CT26.WT-OVA 311539 BALB/c
        Point mutation cell line
        Product Name Product No. Background Actions
        B-hB7-H3 B16-F10 322437 C57BL/6J
        B-hEGFR*L858R*T790M*C797S NCI-H1975 322513