Humanized Tumor Cell Lines

The ability to test potential immuno-oncology therapeutics in vivo requires an intact immune system in the disease model. One way to model disease progression is through the use of murine cancer cell lines. 

Murine cancer cell lines are a useful tool to investigate biological processes that govern tumor growth. Specific applications for murine cancer cell lines include in vitro mechanistic studies, and in vivo syngeneic tumor growth assays. For these syngeneic models, an isolated murine cancer cell line is implanted into immunocompetent mice of the same strain/genetic background. The use of syngeneic models allows for successful implantation of tumor cells that are recognized as “self” by the mouse. 

To facilitate your anti-tumor efficacy studies, Biocytogen offers numerous off-the-shelf humanized murine cancer cell lines. When implanted into our humanized immune-checkpoint mice, which are genetically engineered to express human immune checkpoint proteins, in vivo efficacy evaluation of human immune checkpoint antibodies or inhibitors is possible. 

Don’t see the line you’re looking for? Our gene editing team can generate humanized murine cancer cell lines for your specific needs.

Request a Custom Cell Line Here!

Product Organism Disease
B-Luc LLC1 Mouse Lewis lung carcinoma
B-Tg(hCCL1) MC38 Mus musculus, mouse Colon Carcinoma
B-Tg(mAger) MC38 Mouse Colon carcinoma
B-Tg(mAreg) MC38 Mouse Colorectal cancer
B-Tg(mArtn) MC38 Mouse Colon carcinoma
B-Tg(mCcl2) MC38 Mouse Colon carcinoma
B-Tg(mCd30l) MC38 Mouse Colon carcinoma
B-Tg(mEfemp1) MC38 Mouse Colon carcinoma
B-Tg(mGpa33) MC38 Mouse Colorectal cancer
B-Tg(mTff1) MC38 Mouse Colon carcinoma
B-hAMHR2 ID8 Mouse Ovarian cancer
B-hAMHR2 MC38 Mus musculus, mouse Colon Carcinoma
B-hB7-H3 CT26.WT Mus musculus, mouse Colon Carcinoma
B-hB7-H3 MC38 Mus musculus, mouse Colon Carcinoma
B-hB7-H4 B16-F10 Mus musculus, mouse Melanoma
B-hB7-H4 MC38 Mus musculus, mouse Colon Carcinoma
B-hBCMA MC38 Mus musculus, mouse Colon Carcinoma
B-hC5 MC38 Mus musculus, mouse Colon Carcinoma
B-hCCL2 MC38 Mouse Colon carcinoma
B-hCCR4 MC38 Mus musculus, mouse Colon Carcinoma
B-hCCR4-luc EL4 Mus musculus, mouse Lymphoma
B-hCD155 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD19 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD20 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD24 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD37 MC38 Mus musculus, mouse Colon carcinoma
B-hCD38 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD38-Luc E.G7-OVA Mouse Lymphoma
B-hCD39 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD47 MC38 Mus musculus, mouse Colon Carcinoma
B-hCD73 MC38 Mus musculus, mouse Colon Carcinoma
B-hCEACAM1 MC38 Mus musculus,mouse Colon Carcinoma
B-hCLDN18.2 MC38 Mus musculus, mouse Colon Carcinoma
B-hCLDN6 MC38 Mus musculus, mouse Colon Carcinoma
B-hCXCR2 MC38 Mus musculus, mouse Colon Carcinoma
B-hCXCR4 MC38 Mus musculus, mouse Colon Carcinoma
B-hDLL3 MC38 Mus musculus, mouse Colon Carcinoma
B-hEPCAM MC38 Mus musculus,mouse Colon Carcinoma
B-hFAP MC38 Mus musculus, mouse Colon carcinoma
B-hFGL1 MC38 Mus musculus, mouse Colon Carcinoma
B-hFN14 MC38 Mus musculus, mouse Colon Carcinoma
B-hGPC3 MC38 Mus musculus, mouse Colon Carcinoma
B-hGPC3 MC38 plus Mouse Colon carcinoma
B-hGPRC5D MC38 Mus musculus, mouse Colon Carcinoma
B-hGUCY2C MC38 Mouse Colon carcinoma
B-hHER2 MC38 Mus musculus, mouse Colon Carcinoma
B-hHLA-E MC38 plus Mus musculus, mouse Colon Carcinoma
B-hHVEM MC38 Mus musculus, mouse Colon Carcinoma
B-hLAIR1-luc EL4 Mus musculus, mouse Lymphoma
B-hLILRB4 MC38 Mus musculus, mouse Colon carcinoma
B-hLILRB4 luc EL4 Mus musculus, mouse Lymphoma
B-hMSLN ID8 Mouse Ovarian Cancer
B-hNECTIN4 MC38 Mus musculus, mouse Colon carcinoma
B-hPD-L1 MC38 Mus musculus, mouse Colon Carcinoma
B-hPD-L1 MC38 Plus Mus musculus, mouse Colon Carcinoma
B-hPD-L1 low B16-F10 Mus musculus, mouse Melanoma
B-hPD-L1 low MC38 Mus musculus, mouse Colon Carcinoma
B-hPD-L1 low MC38 plus Mus musculus, mouse Colon Carcinoma
B-hPD-L1 plus/hCD47 MC38 Mus musculus, mouse Colon Carcinoma
B-hPD-L1 plus/hCEA MC38 Mus musculus, mouse Colon Carcinoma
B-hPD-L1/hB7-H3 MC38 Mouse Colon carcinoma
B-hPD-L2 MC38 Mus musculus, mouse Colon Carcinoma
B-hPSMA MC38 Mus musculus, mouse Colon carcinoma
B-hROR1 MC38 Mus musculus, mouse Colon Carcinoma
B-hSIGLEC15 MC38 Mus musculus, mouse Colon Carcinoma
B-hTF MC38 Mus musculus, mouse Colon Carcinoma
B-hTNFR2 MC38 Mus musculus, mouse Colon Carcinoma
B-hTPBG MC38 Mus musculus, mouse Colon Carcinoma
B-hTROP2 MC38 plus Mus musculus, mouse Colon Carcinoma
B-luc A20 Mus musculus, mouse Reticulum cell sarcoma
B-luc B16-F10 Mus musculus, mouse Melanoma
B-luc EL4 Mus musculus, mouse lymphoma
B-mSiglec15 MC38 Mus musculus, mouse Colon Carcinoma