Basic Information

Strain name
C57BL/6-Mmp7tm1(MMP7)Bcgen/Bcgen
Common name
B-hMMP7 mice
Background
C57BL/6
Catalog number
112823
Aliases
MMP-7, MPSL1, PUMP-1
NCBI gene ID

Targeting strategy

Gene targeting strategy for B-hMMP7 mice. 

The exons 1~6 of mouse Mmp7 gene that encode the full-length protein and 3’UTR were replaced by human MMP7 exons 1~6 in B-hMMP7 mice. 

Protein expression analysis in serum

Strain specific MMP7 expression analysis in wild-type C57BL/6 mice and heterozygous humanized B-hMMP7 mice by ELISA. Serum was collected from wild-type C57BL/6 mice (+/+) and heterozygous B-hMMP7 mice (H/+) (n=3). Protein expression level of MMP7 was analyzed by ELISA. Mouse MMP7 was detectable in wild-type C57BL/6 mice and heterozygous B-hMMP7 mice. Human MMP7 was exclusively detectable in heterozygous B-hMMP7 mice. Values are expressed as mean ± SEM.

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