B-hCLU mice

C57BL/6-Clutm1(CLU)Bcgen/Bcgen • 111430

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B-hCLU mice

Catalog Number: 111430
Strain Name: C57BL/6-Clutm1(CLU)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 1191 (Human)
Aliases: CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
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B-hCLU mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCLU mice.
      The exon 2-9 of mouse Clu gene that encode the full-length protein were replaced by human CLU exon 2-9 in B-hCLU mice.

      Protein expression analysis

      Strain specific CLU expression analysis in homozygous B-hCLU mice by ELISA. Serum were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCLU mice (H/H), and analyzed by ELISA with species-specific CLU ELISA kit. Mouse CLU was detectable in wild-type mice. Human CLU was exclusively detectable in homozygous B-hCLU mice, but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCLU mice] (Cat# 111430) was purchased from Biocytogen.