B-hCXCR3 mice

C57BL/6N-Cxcr3tm1(CXCR3)Bcgen/Bcgen • 110969

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B-hCXCR3 mice

Product nameB-hCXCR3 mice
Catalog number110969
Strain nameC57BL/6N-Cxcr3tm1(CXCR3)Bcgen/Bcgen
Strain backgroundC57BL/6N
AliasesGPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
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  • Targeting strategy
  • Phenotypic analysis

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Targeting strategy

Gene targeting strategy for B-hCXCR3 mice. The full coding region of mouse Cxcr3 was replaced by human CXCR3 coding region sequences in B-hCXCR3 mice.

Protein expression analysis
Strain specific CXCR3 expression analysis in homozygous B-hCXCR3 mice by FACS. Splenocytes were collected from wild type (+/+) and homozygous B-hCXCR3 mice (H/H) stimulated with anti-mCD3ε antibody in vivo, and analyzed by FACS with species-specific anti-CXCR3 antibody. Mouse CXCR3 was detectable in wild type mice. Human CXCR3 was exclusively detectable in homozygous B-hCXCR3 mice but not in wild type mice.