C57BL/6-Ddr1tm1(DDR1)Bcgen/Bcgen • 111121
| Product name | B-hDDR1 mice |
|---|---|
| Catalog number | 111121 |
| Strain name | C57BL/6-Ddr1tm1(DDR1)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| Aliases | CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A |
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Targeting strategyGene targeting strategy for B-hDDR1 mice. The exons 3-12 of mouse Ddr1 gene that encode the extracellular sequences were replaced by human DDR1 exons 2-11 in B-hDDR1 mice.
mRNA expression analysis
Protein expression analysis
Strain specific DDR1 expression analysis in homozygous B-hDDR1 mice by western blot. Brain collected from wild-type C57BL/6 mice (+/+) and homozygous B-hDDR1 mice (H/H), and analyzed by western blot with DDR1 antibodies. Human DDR1 was exclusively detectable in homozygous B-hDDR1 but not in wild-type mice. Mouse DDR1 was detectable in wild-type mice and homozygous B-hDDR1. The first DDR1 antibody is a human-specific antibody and the other is a human-mouse cross-recognition antibody.
