C57BL/6-Igs2tm2(DR4)Bcgen/Bcgen • 111986
| Product name | B-hDR4 mice |
|---|---|
| Catalog number | 111986 |
| Strain name | C57BL/6-Igs2tm2(DR4)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| Aliases | TNFRSF10A, APO2, CD261, TRAILR1, TRAILR-1 |
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DescriptionDR4 is 56 kD member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261.
It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.
The whole human DR4 genome was inserted at Hipp11 (H11) locus in B-hDR4 mice.
Human DR4 was detectable in homozygous B-hDR4 mice stimulated with anti-CD3ε in vivo but not in wild-type mice.
Targeting strategyGene targeting strategy for B-hDR4 mice. The whole human DR4 genome was inserted at Hipp11 (H11) locus in B-hDR4 mice.
Protein expression analysis
