C57BL/6-Il33tm1(IL33)Bcgen Il1rl1tm2(IL1RL1)Bcgen/Bcgen • 113079
| Product name | B-hIL33/hST2 mice |
|---|---|
| Catalog number | 113079 |
| Strain name | C57BL/6-Il33tm1(IL33)Bcgen Il1rl1tm2(IL1RL1)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 77152, 17082 |
| Aliases | DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26; T1, ST2, DER4, ST2L, ST2V, FIT-1, IL33R |
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DescriptionBoth mouse and human IL33 induced mouse IL-5 production in wild-type C57BL/6 mice and homozygous B-hIL33/hST2 mice.
OVA/hIL33-induced asthma model: Anti-human IL33 antibody and anti-human ST2 antibody were efficacious in reducing IgE in serum and inflammatory cell infiltration in BALF. H&E staining results showed a significantly reduction in inflammatory cell infiltration in mice treated with anti-human IL33 antibody and anti-human ST2 antibody (in-house) in lung.
